Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACUTE LIVER-FAILURE INDUCED BY CARBAMAZEP INE
Autore:
MARTINEZ P; DEETXABARRI SG; ERENO C; LOPEZ G; HINOJAL C; TEIRA R;
Indirizzi:
HOSP BASURTO,SERV MED INTERNA,AVDA MONTEVIDEO 18 E-48013 BILBAO SPAIN
Titolo Testata:
Revista espanola de enfermedades digestivas
fascicolo: 2, volume: 84, anno: 1993,
pagine: 124 - 126
SICI:
1130-0108(1993)84:2<124:ALIBCI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
SPA
Keywords:
HEPATITIS TOXIC; CARBAMAZEPINE; ACUTE LIVER FAILURE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
P. Martinez et al., "ACUTE LIVER-FAILURE INDUCED BY CARBAMAZEP INE", Revista espanola de enfermedades digestivas, 84(2), 1993, pp. 124-126

Abstract

Acute liver toxicity caused by carbamazepine is a well known though infrequent event. Severe toxicity with hepatocellular insufficiency is even more rare. A case is presented of a patient who suffered of partial epilepsy on treatment with valproate and carbamazepine, who was admitted because of severe acute liver insufficiency atributable to carbamazepine. He had started treatment with the latter drug two weeks earlier, when he developed fever, jaundice, rash and signs of encephalophaty in association with elevation in serum transaminases levels and a decrease in prothrombine index (24%). Discontinuation of both antiepileptic drugs, together with the usual supportive measures, was followed by a complete resolution. Valproate was restarted without complications. Liver biopsy suggested acute hepatitis of drug-related origin. Granulomas or esteatosis were not found. The histologic picture together with the relation between carbamazepine administration and the developement of hepatotoxicity allow us to dismiss valproate as the possible causal agent of this patient's disease. Therefore, we believe it was anacute hepatocellular failure secondary to carbamazepine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 21:34:57