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Titolo:
CENTRAL ANGIOTENSIN-CONVERTING ENZYME-BLOCKADE AND THIRST
Autore:
SAAD WA; LUIZ AC; CAMARGO LAA; MENANI JV; RENZI A; SILVEIRA JEN;
Indirizzi:
UNESP,FAC ODONTOL,DEPT FISIOL,RUA HUMAITA 1680 BR-14801 ARARAQUARA SPBRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 9, volume: 26, anno: 1993,
pagine: 999 - 1007
SICI:
0100-879X(1993)26:9<999:CAEAT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CENTRAL-NERVOUS-SYSTEM; SUBFORNICAL ORGAN; CIRCUMVENTRICULAR ORGANS; CEREBROSPINAL-FLUID; BRAIN; DRINKING; INHIBITION; CAPTOPRIL; WATER;
Keywords:
WATER INTAKE; DEHYDRATION; HYPOVOLEMIA; ANGIOTENSIN-II; LISINOPRIL; MEDIAL PREOPTIC AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Saad et al., "CENTRAL ANGIOTENSIN-CONVERTING ENZYME-BLOCKADE AND THIRST", Brazilian journal of medical and biological research, 26(9), 1993, pp. 999-1007

Abstract

1. The effect of lisinopril, a potent inhibitor of angiotensin converting enzyme (ACE), injected into the medial preoptic area (MPOA) on water intake was investigated in male Holtzman rats (200-250 g). 2. Injection of lisinopril (2 mug/mul) into the MPOA abolished the water intake induced by subcutaneous (sc) injection of isoprenaline (100%) and water deprivation (90%) and drastically reduced the water intake induced by sc injection of polyethyleneglycol (60%). A small reduction of water intake induced by lisinopril was also observed 90 and 120 min after sc hypertonic saline (N = 10 for each group). 3. These results suggest that central ACE activation, particularly in the MPOA, plays an important role in the dipsogenic responses induced by the agents studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 14:28:41