Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE EPSTEIN-BARR-VIRUS GLYCOPROTEIN-110 CARBOXY-TERMINAL TAIL DOMAIN IS ESSENTIAL FOR LYTIC VIRUS-REPLICATION
Autore:
LEE SK; LONGNECKER R;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,303 E CHICAGRO AVE CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED CHICAGO IL 60611
Titolo Testata:
Journal of virology
fascicolo: 5, volume: 71, anno: 1997,
pagine: 4092 - 4097
SICI:
0022-538X(1997)71:5<4092:TEGCTD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS-1; B-CELLS; MARMOSET LEUKOCYTES; EPITHELIAL-CELLS; GB-GLYCOPROTEIN; AMINO-ACIDS; IDENTIFICATION; EBV; RECEPTOR; TYPE-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Lee e R. Longnecker, "THE EPSTEIN-BARR-VIRUS GLYCOPROTEIN-110 CARBOXY-TERMINAL TAIL DOMAIN IS ESSENTIAL FOR LYTIC VIRUS-REPLICATION", Journal of virology, 71(5), 1997, pp. 4092-4097

Abstract

To investigate the importance of the Epstein-Barr virus (EBV) glycoprotein 110 (gp110) tail domain in the intracellular localization of gp110 and virus lytic replication, three carboxy-terminal truncation mutants of gp110 were constructed. Deletion of 16 amino acids from the carboxyl-terminal tail resulted in gp110 intracellular localization whichwas indistinguishable from that of wild-type gp110, whereas deletion of either 41 or 56 amino acids from the carboxyl-terminal tail of gp110 resulted in loss of retention of gp110 in the endoplasmic reticulum and nuclear membrane. None of the gp110 truncation mutants was able tocomplement EBV(gp110-)(+) lymphoblastoid cell lines in transformationassays, indicating the importance of the gp110 tail domain in virus lytic replication. In electron microscopy analysis, no nucleocapsids orenveloped viruses were detected in EBV(gp110-)(+) lymphoblastoid celllines induced for lytic replication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:05:26