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Titolo:
AN HLA-B REGULATORY ELEMENT BINDS A FACTOR IMMUNOLOGICALLY RELATED TOTHE UPSTREAM STIMULATION FACTOR
Autore:
GIRDLESTONE J;
Indirizzi:
MRC,MOLEC BIOL LAB,HILLS RD CAMBRIDGE CB2 2QH ENGLAND
Titolo Testata:
Immunogenetics
fascicolo: 6, volume: 38, anno: 1993,
pagine: 430 - 436
SICI:
0093-7711(1993)38:6<430:AHREBA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I GENES; MAJOR HISTOCOMPATIBILITY COMPLEX; ADENOVIRUS-12 TRANSFORMED-CELLS; IMMUNODEFICIENCY-VIRUS TYPE-1; TUMOR-NECROSIS-FACTOR; LOOP HELIX PROTEIN; RNA POLYMERASE-II; NF-KAPPA-B; TRANSCRIPTION FACTOR; C-MYC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
J. Girdlestone, "AN HLA-B REGULATORY ELEMENT BINDS A FACTOR IMMUNOLOGICALLY RELATED TOTHE UPSTREAM STIMULATION FACTOR", Immunogenetics, 38(6), 1993, pp. 430-436

Abstract

HLA-A and -B are expressed by most cell types, and their levels can be increased by treatment with interferons (IFNs). The relative basal levels of HLA-A and -B expression can vary, and HLA-B loci are induced much more strongly by IFNs. Constitutive activity is dependent on an upstream enhancer (ENH) which contains a rel (KBF, NFkappaB) binding motif, and induction is mediated by an interferon response element (IRE)which binds members of the IRF family. Reported here is the identification of a regulatory element, 'R', which overlaps the IRE of HLA-B loci, but which is absent from the equivalent region of HLA-A or H2 class I genes. The core of the element, CACGAG, is bound by a nuclear factor which is recognized by an antiserum raised against the upstream stimulation factor (USF), a member of the helix-loop-helix/leucine zipperfamily. The use of reporter gene constructs shows that mutation of the R element results in increased induction by IFNalpha in some cell lines, which appears to be due to competitive binding of USF with IRF proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:44:09