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Titolo:
IMPORT OF THE GLUCOCORTICOID RECEPTOR INTO RAT-LIVER MITOCHONDRIA IN-VIVO AND IN-VITRO
Autore:
DEMONACOS C; TSAWDAROGLOU NC; DJORDJEVICMARKOVIC R; PAPALOPOULOU M; GALANOPOULOS V; PAPADOGEORGAKI S; SEKERIS CE;
Indirizzi:
NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL GR-5011 ATHENS GREECE NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL GR-5011 ATHENS GREECE UNIV IRAKLION,FORTH,INST MOLEC BIOL & BIOTECHNOL IRAKLION GREECE UNIV IRAKLION,DEPT BIOL IRAKLION GREECE
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 3, volume: 46, anno: 1993,
pagine: 401 - 413
SICI:
0960-0760(1993)46:3<401:IOTGRI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C-OXIDASE; RNA-SYNTHESIS; THYROID-HORMONE; DEXAMETHASONE TREATMENT; RIBONUCLEIC-ACID; PROTEIN IMPORT; STIMULATION; NUCLEI; CELLS; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
C. Demonacos et al., "IMPORT OF THE GLUCOCORTICOID RECEPTOR INTO RAT-LIVER MITOCHONDRIA IN-VIVO AND IN-VITRO", Journal of steroid biochemistry and molecular biology, 46(3), 1993, pp. 401-413

Abstract

Administration of inducing doses of dexamethasone (10 mug/100 g) to adrenalectomized rats results, within 2-5 min, in import of the glucocorticoid receptor from liver cytoplasm into mitochondria, as demonstrated by Western blotting and by electron microscopy. Furthermore, glucocorticoid receptor (GR) synthesized in an in vitro reticulocyte system programmed with the respective mRNA, enters within minutes to added rat liver mitochondria in the form of intact GR, as demonstrated by Western blotting using either monoclonal or polyclonal antibodies against different domains of GR. In vitro studies show that the import is dependent on temperature and/or activation of the hormone-GR complex. These results, in connection with the presence in the human and rodent mitochondrial genome of sequences showing partial homology to the nuclearglucocorticoid response elements, support the hypothesis that the well documented effects of glucocorticoids on mitochondrial functions result from a direct interaction of the GR complex with the mitochondrialgenome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:54:14