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Titolo:
EFFECT OF DECENTRALIZATION OR CONTRALATERAL GANGLIONECTOMY ON OBSTRUCTION-INDUCED HYPERTROPHY OF RAT URINARY-BLADDER MUSCLE AND PELVIC GANGLION
Autore:
GABELLA G; UVELIUS B;
Indirizzi:
UNIV LONDON UNIV COLL,DEPT ANAT,GOWER ST LONDON WC1E 6BT ENGLAND LUND UNIV,DEPT UROL S-22101 LUND SWEDEN
Titolo Testata:
Journal of neurocytology
fascicolo: 9, volume: 22, anno: 1993,
pagine: 827 - 834
SICI:
0300-4864(1993)22:9<827:EODOCG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; INNERVATION; PATHWAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
G. Gabella e B. Uvelius, "EFFECT OF DECENTRALIZATION OR CONTRALATERAL GANGLIONECTOMY ON OBSTRUCTION-INDUCED HYPERTROPHY OF RAT URINARY-BLADDER MUSCLE AND PELVIC GANGLION", Journal of neurocytology, 22(9), 1993, pp. 827-834

Abstract

After urethral obstruction the musculature of the rat urinary bladderundergoes extensive hypertrophy, irrespective of whether its innervation is intact or whether one of the two pelvic ganglia has been decentralized or excised. Even the excision of both ganglia does not inhibitmuscle hypertrophy. The presence of nerves is not a prerequisite for the muscle growth to occur. The stimulus for growth resides in the bladder itself, and the present and previous observations are in agreement with the notion that the distension of the muscle is a primary stimulus for muscle growth. With bladder hypertrophy, the pelvic ganglion neurons undergo hypertrophy, even when they are devoid of their preganglionic input. Synaptic connection with the preganglionic fibres and stimuli from the spinal cord are not prerequisites for neuronal hypertrophy. However, the hypertrophy is less marked in the decentralized ganglion neurons than in the neurons of the contralateral intact ganglion. With bladder hypertrophy and contralateral ganglionectomy, the neuronal hypertrophy is greater than with either procedure alone, suggestingthat the two forms of neuronal growth stimulation can be added to each other.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:28:16