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Titolo:
NEUROTROPHIC EFFECTS OF NMDA RECEPTOR ACTIVATION ON DEVELOPING CEREBELLAR GRANULE CELLS
Autore:
BURGOYNE RD; GRAHAM ME; CAMBRAYDEAKIN M;
Indirizzi:
UNIV LIVERPOOL,PHYSIOL LAB,POB 147 LIVERPOOL L69 3BX ENGLAND UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Journal of neurocytology
fascicolo: 9, volume: 22, anno: 1993,
pagine: 689 - 695
SICI:
0300-4864(1993)22:9<689:NEONRA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; DEVELOPING SPINAL-CORD; PROTEIN-KINASE-C; RAT CEREBELLUM; GLUTAMATE RECEPTORS; NEURITE OUTGROWTH; AMINO-ACIDS; EXPRESSION; CULTURE; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Burgoyne et al., "NEUROTROPHIC EFFECTS OF NMDA RECEPTOR ACTIVATION ON DEVELOPING CEREBELLAR GRANULE CELLS", Journal of neurocytology, 22(9), 1993, pp. 689-695

Abstract

Glutamate acting on N-methyl-D-aspartate (NMDA) receptors controls a variety of aspects of neuronal plasticity in the adult and developing brain. This review summarizes its effects on developing cerebellar granule cells. The glutamatergic mossy fibre input to cerebellar granule cells exerts a neurotrophic effect on these cells during development. The investigation of potential neurotrophic agents can be carried out using enriched granule cell cultures. Considerable evidence now indicates that glutamate acting on N-methyl-D-aspartate receptors is an important neurotrophic factor that regulates granule cell development. In culture, neurite growth, differentiation and cell survival are all simulated by N-methyl-D-aspartate receptor activation. The intracellular pathways involved following Ca2+ entry through the N-methyl-D-aspartate receptor channel are beginning to be elucidated. The cerebellar granule cell culture system may provide an ideal model to investigate the molecular mechanisms involved in long term N-methyl-D-aspartate receptor-mediated changes in neuronal function.

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Documento generato il 13/08/20 alle ore 14:37:33