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Titolo:
INTERACTION BETWEEN PRP11 AND SPP91 YEAST SPLICING FACTORS AND CHARACTERIZATION OF A PRP9-PRP11-SPP91 COMPLEX
Autore:
LEGRAIN P; CHAPON C;
Indirizzi:
INST PASTEUR,DEPT BIOL MOLEC,UNITE GENET MOLEC F-75724 PARIS FRANCE
Titolo Testata:
Science
fascicolo: 5130, volume: 262, anno: 1993,
pagine: 108 - 110
SICI:
0036-8075(1993)262:5130<108:IBPASY>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRE-MESSENGER-RNA; U1 SNRNP; PROTEIN; GENES; BINDING; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P. Legrain e C. Chapon, "INTERACTION BETWEEN PRP11 AND SPP91 YEAST SPLICING FACTORS AND CHARACTERIZATION OF A PRP9-PRP11-SPP91 COMPLEX", Science, 262(5130), 1993, pp. 108-110

Abstract

Several proteins are involved in the early steps of the spliceosome assembly pathway. Protein-protein interactions have been identified between two Saccharomyces cerevisiae yeast splicing factors, PRP9 and SPP91. Here it is demonstrated that protein-protein interactions occur between SPP91 and PRP11. The combination of the prp9-1 mutant and a truncated prp11 mutant exhibits a synthetic lethal phenotype, suggestive of a common biochemical defect. The PRP9 and PRP11 proteins do not interact directly, but the PRP9 and PRP11 molecules can simultaneously bind SPP91 to form a three-molecule complex. Structurally and functionally related proteins are found in mammalian cells and are associated in a single biochemical fraction. This strongly suggests that the PRP9-SPP91-PRP11 complex is a key element of the splicing machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 11:31:31