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Titolo:
NEUROVASCULAR PERMEABILITY AND FIBRIN DEPOSITION IN THE CENTRAL NEURAXIS OF LEWIS RATS WITH CELL-TRANSFERRED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RELATIONSHIP TO CLINICAL AND HISTOPATHOLOGICAL FEATURES OF THE DISEASE
Autore:
KOH CS; GAUSAS J; PATERSON PY;
Indirizzi:
SHINSHU UNIV,SCH MED,DEPT MED NEUROL,ASAHI 3-1-1 MATSUMOTO NAGANO 390JAPAN NORTHWESTERN UNIV,SCH DENT,DEPT MICROBIOL IMMUNOL CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL IMMUNOL CHICAGO IL 60611 COLL ARTS & SCI,DEPT NEUROBIOL PHYSIOL EVANSTON IL 00000
Titolo Testata:
Journal of neuroimmunology
fascicolo: 2, volume: 47, anno: 1993,
pagine: 141 - 145
SICI:
0165-5728(1993)47:2<141:NPAFDI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY; GUINEA-PIGS;
Keywords:
CELL-TRANSFERRED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; BLOOD BRAIN BARRIER; FIBRIN DEPOSITS; EDEMA; NEUROLOGICAL SIGNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Koh et al., "NEUROVASCULAR PERMEABILITY AND FIBRIN DEPOSITION IN THE CENTRAL NEURAXIS OF LEWIS RATS WITH CELL-TRANSFERRED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RELATIONSHIP TO CLINICAL AND HISTOPATHOLOGICAL FEATURES OF THE DISEASE", Journal of neuroimmunology, 47(2), 1993, pp. 141-145

Abstract

Abrupt increases in blood-brain barrier (BBB) permeability were detected by the dual-isotope technique, coinciding with evidence of activation of coagulation cascade, occurred 1 day prior to appearance of clinical neurological signs of experimental allergic encephalomyelitis (EAE) and in conjunction with initial detectable cell infiltration. Maximal increase of BBB permeability was observed on the first day of clinical signs, which was 2 days prior to maximum severity of clinical abnormalities and 1 day in advance of the greatest number of central nervous system (CNS) fibrin deposits and perivascular cellular infiltration. Returning of increased BBB permeability and CNS perivascular fibrin deposits to normal levels was demonstrated prior to complete remissionof neurological signs. Considerable CNS perivascular cellular infiltrates, however, lasted after complete remission of neurological signs. These findings indicate that increased permeability of the BBB, in association with activation of the coagulation cascade, is the earliest expressions of immune effector activity of experimental allergic EAE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:36:00