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Titolo:
EFFECT OF NALOXONE ON THE HABITUATION OF NOVELTY-INDUCED HYPOALGESIA - THE COLLATERAL INHIBITION HYPOTHESIS REVISITED
Autore:
ROCHFORD J; DAWES P;
Indirizzi:
MCGILL UNIV,DOUGLAS HOSP RES CTR,DEPT PSYCHIAT,6875 BLVD LASALLE VERDUN H4H 1R3 PQ CANADA CONCORDIA UNIV,CTR STUDIES BEHAV NEUROBIOL,DEPT PSYCHOL MONTREAL H3G 1M8 QUEBEC CANADA
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 46, anno: 1993,
pagine: 117 - 123
SICI:
0091-3057(1993)46:1<117:EONOTH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED ANALGESIA; LOCUS COERULEUS NEURONS; WATER SWIM ANALGESIA; CROSS-TOLERANCE; FORMALIN TEST; HOT-PLATE; RAT-BRAIN; MORPHINE; CLONIDINE; YOHIMBINE;
Keywords:
NALOXONE; NOVELTY-INDUCED HYPOALGESIA; ALPHA-2-RECEPTOR; NORADRENALINE; OPIOID; NONOPIOID; HABITUATION RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J. Rochford e P. Dawes, "EFFECT OF NALOXONE ON THE HABITUATION OF NOVELTY-INDUCED HYPOALGESIA - THE COLLATERAL INHIBITION HYPOTHESIS REVISITED", Pharmacology, biochemistry and behavior, 46(1), 1993, pp. 117-123

Abstract

Repeated daily administration of the opiate receptor antagonist naloxone prior to hotplate tests provokes longer paw-lick latencies by attenuating the habituation of novelty-induced hypoalgesia. This hypoalgesia has been found to persist when pain tests are subsequently conducted following saline administration. The present experiments were conducted to determine whether the substrates mediating the hypoalgesia observed during naloxone and saline tests are similar or distinct. Neitherthe hypoalgesia observed during naloxone nor saline tests were affected by the induction of tolerance to the hypoalgesic effect of morphine, suggesting that both effects are mediated by nonopioid antinociceptive mechanisms. Previous work from our laboratory demonstrated that thehypoalgesia observed during naloxone tests is inhibited by clonidine,enhanced by yohimbine, and unaffected by prazosin and phentolamine. In the present article, we report a similar pattern of results for the hypoalgesia observed during saline tests. It is concluded that the substrates mediating both effects are similar. The results are discussed in relation to the possibility that an opioid substrate involved in habituative learning may be inhibitory on a nonopioid antinociceptive substrate.

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Documento generato il 07/07/20 alle ore 22:04:56