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Titolo:
CLONIDINE AND PHENYLEPHRINE INJECTED INTO THE LATERAL PREOPTIC AREA REDUCE WATER-INTAKE IN DEHYDRATED RATS
Autore:
CALLERA JC; CAMARGO LAD; DELUCA LA; MENANI JV; RENZI A; SAAD WA;
Indirizzi:
PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST BR-14801 ARARAQUARA SP BRAZIL PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST BR-14801 ARARAQUARA SP BRAZIL
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 46, anno: 1993,
pagine: 39 - 43
SICI:
0091-3057(1993)46:1<39:CAPIIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTROLATERAL MEDULLA; ANGIOTENSIN-II; DRINKING; ALPHA-2-ADRENOCEPTORS; ALPHA-1-ADRENOCEPTORS; CATECHOLAMINES; BINDING; THIRST; SITES;
Keywords:
WATER INTAKE; PREOPTIC AREA; ALPHA-ADRENOCEPTORS; THIRST; CLONIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Callera et al., "CLONIDINE AND PHENYLEPHRINE INJECTED INTO THE LATERAL PREOPTIC AREA REDUCE WATER-INTAKE IN DEHYDRATED RATS", Pharmacology, biochemistry and behavior, 46(1), 1993, pp. 39-43

Abstract

In the present study, we investigated the effect of phenylephrine andclonidine (alpha1- and alpha2-adrenoceptor agonists, respectively) injected into the lateral preoptic area (LPOA) on the water intake induced by water deprivation in rats. In addition, the effects of prior injections of prazosin and yohimbine (alpha1- and alpha2-adrenoceptor antagonists, respectively) into the LPOA on the antidipsogenic action of phenylephrine and clonidine were investigated. After 30 h of water deprivation, the water intake of rats in a control experiment (saline injection) was 10.5 +/- 0.8 ml/h. Injection of clonidine (5, 10, 20, and 40 nmol) into the LPOA reduced water intake to 6.3 +/- 0.9, 4.9 +/- 0.8, 3.6 +/- 1.0, and 2.2 +/- 0.7 ml/h, respectively. Similar reductionsoccurred after injection of 80 and 160 nmol phenylephrine into the LPOA (6.2 +/- 1.6 and 4.8 +/- 1.3 ml/h, respectively). Pretreatment withprazosin (40 nmol) abolished the antidipsogenic action of an 80-nmol dose of phenylephrine (11.3 +/- 1.1 ml/h) and reduced the effect of a 20-nmol dose of clonidine (7.4 +/- 1.4 ml/h). Yohimbine (20, 40, and 80 nmol), previously injected, produced no significant changes in the effects of either phenylephrine or clonidine. The present results show that phenylephrine and clonidine injected into the LPOA induce an antidipsogenic effect in water-deprived rat. They also suggest an involvement of alpha1-adrenoceptors in this effect. A possible participation of imidazole receptors in the effect of clonidine should also be taken into account.

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Documento generato il 30/11/20 alle ore 16:16:03