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Titolo:
FURANOCOUMARIN METABOLISM IN PAPILIO-POLYXENES - BIOCHEMISTRY, GENETIC-VARIABILITY, AND ECOLOGICAL SIGNIFICANCE
Autore:
BERENBAUM MR; ZANGERL AR;
Indirizzi:
UNIV ILLINOIS,DEPT ENTOMOL,320 MORRILL HALL,505 S GOODWIN URBANA IL 61801
Titolo Testata:
Oecologia
fascicolo: 3, volume: 95, anno: 1993,
pagine: 370 - 375
SICI:
0029-8549(1993)95:3<370:FMIP-B>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLACK SWALLOWTAIL; DRUG METHOXSALEN; PARSNIP WEBWORM; WILD PARSNIP; INSECT; CYTOCHROME-P-450; DEFENSE; DETOXIFICATION; CATERPILLARS; RESISTANCE;
Keywords:
PAPILIO-POLYXENES; DETOXIFICATION; METABOLISM; FURANOCOUMARIN; HERBIVORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Berenbaum e A.R. Zangerl, "FURANOCOUMARIN METABOLISM IN PAPILIO-POLYXENES - BIOCHEMISTRY, GENETIC-VARIABILITY, AND ECOLOGICAL SIGNIFICANCE", Oecologia, 95(3), 1993, pp. 370-375

Abstract

The ubiquitous occurrence of series of biosynthetically related plantsecondary compounds within individual species has given rise to the suggestion that such multiplicity is adaptive; one possible mechanism that would serve to maintain such within-plant diversity is analog synergism. In a series of experiments, we provide evidence that synergism may account for the presence of multiple structurally related furanocoumarins in apiaceous plants. The black swallowtail, Papilio polyxenes,feeds exclusively on plant species containing furanocoumarins. Growthof larvae fed parsley leaves treated with both xanthotoxin and angelicin, two furanocoumarins that co-occur widely in swallowtail hostplants, was significantly slower than that of larvae fed leaves with an equimolar concentration of either xanthotoxin or angelicin. A multivariate combination of growth, food consumption and frass excretion differedsignificantly between larvae fed leaves treated with both xanthotoxinand angelicin and larvae fed leaves treated with angelicin alone. In addition, we measured rates of in vitro cytochrome P450-mediated metabolism of three furanocoumarins - bergapten, xanthotoxin, and angelicin. While bergapten and xanthotoxin, both linear furanocoumarins, were metabolized at similar rates (8.07 and 9.86 nmoles/min/g fw caterpillar, respectively), angelicin, an angular furanocoumarin, was metabolizedmore slowly (2.76 nmoles/min/g fw caterpillar). When all three furanocoumarins were assayed together, overall rates of metabolism were significantly reduced, suggesting substrate inhibition. Thus, the pattern of growth of larvae is consistent with the pattern of in vitro metabolism and is evidence in support of analog synergism. In a separate experiment, metabolism of xanthotoxin and angelicin individually and together were compared in six maternal families. Again, angelicin was metabolized more slowly than xanthotoxin and each furanocoumarin inhibited metabolism of the other. That significant family effects were found for rates of metabolism and for the ratio of moles of angelicin metabolized for each mole of xanthotoxin metabolized raises the possibility that genetic variation exists for the rate and specificity of metabolismand suggests that insect herbivores may be able to adapt to analog synergism.

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Documento generato il 27/11/20 alle ore 13:41:19