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Titolo:
HUMAN RECOMBINANT INHIBIN-A SUPPRESSES PLASMA FOLLICLE-STIMULATING-HORMONE TO INTACT LEVELS BUT HAS NO EFFECT ON LUTEINIZING-HORMONE IN CASTRATED RAMS
Autore:
TILBROOK AJ; DEKRETSER DM; CLARKE IJ;
Indirizzi:
MONASH UNIV,DEPT PHYSIOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,INST REPROD & DEV CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,MED CTR,PRINCE HENRYS INST MED RES CLAYTON VIC 3168 AUSTRALIA VICTORIAN INST ANIM SCI WERRIBEE VIC 3030 AUSTRALIA
Titolo Testata:
Biology of reproduction
fascicolo: 4, volume: 49, anno: 1993,
pagine: 779 - 788
SICI:
0006-3363(1993)49:4<779:HRISPF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING HORMONE; BETA MESSENGER-RNA; MALE SHEEP; TESTOSTERONE PROPIONATE; NEGATIVE FEEDBACK; ESTROUS-CYCLE; SECRETION; LH; FSH; FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Tilbrook et al., "HUMAN RECOMBINANT INHIBIN-A SUPPRESSES PLASMA FOLLICLE-STIMULATING-HORMONE TO INTACT LEVELS BUT HAS NO EFFECT ON LUTEINIZING-HORMONE IN CASTRATED RAMS", Biology of reproduction, 49(4), 1993, pp. 779-788

Abstract

This study tested the hypothesis that inhibin is a major negative feedback regulator of FSH secretion but has minimal effects on LH secretion in rams. In experiment 1, castrated rams (wethers) were given either vehicle or human recombinant inhibin A (hr-inhibin) as three s.c. orthree i.v. 50-mug injections 6 h apart or as one 50-mug i.v. injection followed by 100-mug infusion over 12 h. Human recombinant inhibin suppressed plasma FSH while the vehicle had no effect. The greatest suppression in plasma FSH was achieved following i.v. administration of hr-inhibin given either by repeated injection or by infusion. In experiment 2, wethers were given vehicle or a 50-mug i.v. injection followed by 800-mug infusion of hr-inhibin over 12 h. Infusion of hr-inhibin suppressed plasma FSH with a maximal suppression of 53.3% occurring between 15 and 24 h after the start of treatment. During this period, the plasma concentrations of FSH and inhibin were in the range of values for intact rams. Human recombinant inhibin did not influence plasma LH in either experiment. This study demonstrated that physiological treatment with inhibin, in the absence of testosterone, has the capacity tosuppress plasma concentrations of FSH in wethers to the levels found in intact rams.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:45:02