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Titolo:
AN ANIMAL-MODEL OF NEUROPATHIC PAIN - A REVIEW
Autore:
BENNETT GJ;
Indirizzi:
NIDR,NEUROBIOL & ANESTHESIOL BRANCH,BLDG 30,ROOM B-20,9000 ROCKVILLE PIKE BETHESDA MD 20892
Titolo Testata:
Muscle & nerve
fascicolo: 10, volume: 16, anno: 1993,
pagine: 1040 - 1048
SICI:
0148-639X(1993)16:10<1040:AAONP->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE INJURY; EXPERIMENTAL PERIPHERAL NEUROPATHY; EXPERIMENTAL ANESTHESIA DOLOROSA; SPONTANEOUS DISCHARGE; CONSTRICTION INJURY; AFFERENT INPUT; SPINAL-CORD; RAT MODEL; MONONEUROPATHY; BEHAVIOR;
Keywords:
ANIMAL MODELS; CAUSALGIA; PERIPHERAL NEUROPATHY; NEUROPATHIC PAIN; SYMPATHECTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Bennett, "AN ANIMAL-MODEL OF NEUROPATHIC PAIN - A REVIEW", Muscle & nerve, 16(10), 1993, pp. 1040-1048

Abstract

Recent work has succeeded in producing models of painful peripheral neuropathies in laboratory animals. There is evidence that the animals experience both abnormal spontaneous pain and abnormal evoked pains (allodynia and hyperalgesia). Experimental analyses of these models havedemonstrated potential pathophysiologic mechanisms in both the peripheral and central nervous systems; it is likely that the model neuropathic pain syndromes are due to several different mechanisms. One line of evidence suggests that these pain states gradually become centralized due to an excitotoxic effect on spinal cord dorsal horn inhibitory interneurons. The role of the sympathetic nervous system appears to vary, depending on the type of nerve injury and the temporal evolution ofthe syndrome. There is evidence indicating that the abnormality of cutaneous temperature regulation that often accompanies painful peripheral neuropathy is not necessarily due to the activity of sympathetic vasomotor efferents. (C) 1993 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 01:55:30