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Titolo:
DIABETIC NEUROPATHY 3 YEARS AFTER SUCCESSFUL PANCREAS AND KIDNEY-TRANSPLANTATION
Autore:
MULLERFELBER W; LANDGRAF R; SCHEUER R; WAGNER S; REIMERS CD; NUSSER J; ABENDROTH D; ILLNER WD; LAND W;
Indirizzi:
UNIV MUNICH,KLINIKUM INNENSTADT,FRIEDRICH BAUR INST,DEPT INTERNAL MED,ZIEMSSENSTR 1A D-80336 MUNICH GERMANY UNIV MUNICH,DEPT NEUROL W-8000 MUNICH 2 GERMANY UNIV MUNICH,CTR TRANSPLANTAT W-8000 MUNICH 2 GERMANY
Titolo Testata:
Diabetes
fascicolo: 10, volume: 42, anno: 1993,
pagine: 1482 - 1486
SICI:
0012-1797(1993)42:10<1482:DN3YAS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE-CONDUCTION; POLYNEUROPATHY; NORMOGLYCEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W. Mullerfelber et al., "DIABETIC NEUROPATHY 3 YEARS AFTER SUCCESSFUL PANCREAS AND KIDNEY-TRANSPLANTATION", Diabetes, 42(10), 1993, pp. 1482-1486

Abstract

Twenty-seven patients with successful transplantation and a control group of 14 patients with early rejection of the pancreas graft but functioning kidney graft were examined in a prospective study for 3 yr. Before transplantation, all patients had long-standing type I diabetes with advanced secondary complications, including end-stage diabetic nephropathy. After transplantation in the patients of both groups, kidney function was almost normal. Mean HbA1 levels were normal in the group with pancreas graft survival. In the control group, HbA1 levels were, on average, 1.5% higher compared with the group with pancreas survival (P = 0.00005). After 3 yr, the patients with functioning pancreas graft showed fewer symptoms (mean difference 1.0 in a symptom score ranging from 0 to 16, P = 0.004) compared with the control group. No statistically significant difference between both groups concerning clinical signs of polyneuropathy could be observed. In the pancreas and kidney transplantation group, peroneal and median nerve conduction velocities increased 7.2 m/s (P < 0.01) and 3.5 m/s (P < 0.05), respectively,whereas no increase was registered in the control group. The change of median and sural sensory nerve conduction velocities, peroneal and median compound muscle action potentials, and sural and median sensory action potentials was insignificant. In conclusion, although the improvement of clinical symptoms and neurophysiological signs of polyneuropathy was modest in the pancreas and kidney transplantation group, our data suggest that successful pancreas transplantation is able not onlyto halt the progression of diabetic polyneuropathy but also to improve it to some extent even at a far advanced stage.

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Documento generato il 27/10/20 alle ore 10:33:34