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Titolo:
EVIDENCE FOR ESTROGEN SYNTHESIS IN ADENOMYOTIC TISSUES
Autore:
YAMAMOTO T; NOGUCHI T; TAMURA T; KITAWAKI J; OKADA H;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL,465 KAJII MACHI,KAWARAMACHI DORI,KAMIGYO KU KYOTO 602 JAPAN
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 3, volume: 169, anno: 1993,
pagine: 734 - 738
SICI:
0002-9378(1993)169:3<734:EFESIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; AROMATASE CYTOCHROME-P-450; UTERINE ADENOMYOSIS; UTERUS; STEROIDOGENESIS; ENDOMETRIOSIS; BIOSYNTHESIS;
Keywords:
AROMATASE; ESTRONE SULFATASE; STEROIDOGENESIS; ADENOMYOSIS; DANAZOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamamoto et al., "EVIDENCE FOR ESTROGEN SYNTHESIS IN ADENOMYOTIC TISSUES", American journal of obstetrics and gynecology, 169(3), 1993, pp. 734-738

Abstract

OBJECTIVE: To investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis. STUDY DESIGN: Aromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatography, and cocrystallization. The effects of danazol on the activity of these enzymes were also examined. Moreover, localization of aromatase in eutopic and ectopic endometrial tissues was immunohistochemically examined with antihuman placental aromatase cytochrome P-450 antibody. RESULTS: Aromatase and estrone sulfatase activities were detected in ectopic endometrium. The activity of these enzymes was significantly suppressed by danazol. In addition, aromatase was immunohistochemically detected in glandular cells of eutopic and ectopic endometrial tissues. CONCLUSIONS: The results suggest that estrogen is synthesized in the eutopic and ectopic endometrial tissues of women with uterine adenomyosis and that it may affect the growth of adenomyosis. Danazol suppressed synthesis of estrogen in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:01:41