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Titolo:
A PROSPECTIVE TRIAL OF PRENATAL SCREENING FOR DOWN-SYNDROME BY MEANS OF MATERNAL SERUM ALPHA-FETOPROTEIN, HUMAN CHORIONIC-GONADOTROPIN, ANDUNCONJUGATED ESTRIOL
Autore:
BURTON BK; PRINS GS; VERP MS;
Indirizzi:
MICHAEL REESE HOSP & MED CTR,CTR MED & REPROD GENET,2929 S ELLIS AVE CHICAGO IL 60616 MICHAEL REESE HOSP & MED CTR,REPROD BIOL LAB CHICAGO IL 60616 UNIV CHICAGO,DEPT OBSTET & GYNECOL CHICAGO IL 60637 UNIV ILLINOIS,COLL MED,DEPT PEDIAT CHICAGO IL 60612 UNIV ILLINOIS,COLL MED,DEPT OBSTET & GYNECOL CHICAGO IL 60612
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 3, volume: 169, anno: 1993,
pagine: 526 - 530
SICI:
0002-9378(1993)169:3<526:APTOPS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWNS-SYNDROME; 2ND TRIMESTER; PREGNANCIES; ABNORMALITIES; TRIPLOIDY;
Keywords:
ALPHA-FETOPROTEIN; DOWN SYNDROME SCREENING; CHROMOSOME ANOMALIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
B.K. Burton et al., "A PROSPECTIVE TRIAL OF PRENATAL SCREENING FOR DOWN-SYNDROME BY MEANS OF MATERNAL SERUM ALPHA-FETOPROTEIN, HUMAN CHORIONIC-GONADOTROPIN, ANDUNCONJUGATED ESTRIOL", American journal of obstetrics and gynecology, 169(3), 1993, pp. 526-530

Abstract

OBJECTIVE: Our purpose was to prospectively evaluate the effectiveness of prenatal screening for Down syndrome by means of multiple serum markers. STUDY DESIGN: Alpha-fetoprotein, human chorionic gonadotropin,and unconjugated estriol were measured in 8233 midtrimester serum samples, including 7492 from women < 35 years old and 741 from women greater-than-or-equal-to 35 years old. Down syndrome risks were computed by means of age and all three markers. Further testing was recommended for patients with a risk greater-than-or-equal-to 1:270. Testing for trisomy 18 was recommended for patients with an alpha-fetoprotein less-than-or-equal-to 0.70 multiples of the median, human chorionic gonadotropin less-than-or-equal-to 0.50 multiples of the median, and unconjugated estriol less-than-or-equal-to 0.55 multiples of the median. RESULTS: Of women screened initially 10.4% had a Down syndrome risk greater-than-or-equal-to 1:270; 10 of 12 known cases of Down syndrome were identified. One abnormality was detected for every 33 amniocenteses performed in this group. Of 0.4% of patients at increased risk for trisomy18, two cases of trisomy 18 and one of triploidy were found. CONCLUSION: Multiple marker screening is effective in identifying the majorityof fetal chromosome anomalies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:59:46