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Titolo:
NEUROIMAGING OF JUVENILE PILOCYTIC ASTROCYTOMAS - AN ENIGMA
Autore:
FULHAM MJ; MELISI JW; NISHIMIYA J; DWYER AJ; DICHIRO G;
Indirizzi:
NINCDS,NEUROIMAGING BRANCH,RM 1C451,BLDG 10,9000 ROCKVILLE PIKE BETHESDA MD 20892 NINCDS,NEUROIMAGING BRANCH,RM 1C451,BLDG 10,9000 ROCKVILLE PIKE BETHESDA MD 20892 NINCDS,CLIN NEUROPHARMACOL SECT BETHESDA MD 20892 NIH,CTR CLIN,DEPT DIAGNOST RADIOL BETHESDA MD 20892
Titolo Testata:
Radiology
fascicolo: 1, volume: 189, anno: 1993,
pagine: 221 - 225
SICI:
0033-8419(1993)189:1<221:NOJPA->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MONOCLONAL-ANTIBODY KI-67; HUMAN-BRAIN-TUMORS; NERVOUS-SYSTEM TUMORS; GLUCOSE-TRANSPORTER; HUMAN GLIOMAS; CEREBELLAR ASTROCYTOMA; CEREBRAL HEMISPHERES; BROMODEOXYURIDINE; RECURRENCE;
Keywords:
BRAIN NEOPLASMS; BRAIN NEOPLASMS; BRAIN NEOPLASMS, MR; BRAIN NEOPLASMS, RADIONUCLIDE STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Fulham et al., "NEUROIMAGING OF JUVENILE PILOCYTIC ASTROCYTOMAS - AN ENIGMA", Radiology, 189(1), 1993, pp. 221-225

Abstract

PURPOSE: To present the imaging, metabolic, and clinical data obtained in five patients with juvenile pilocytic astrocytomas (JPAs) and discuss the paradoxical neuroimaging findings. MATERIALS AND METHODS: Five patients with JPAs who had undergone structural imaging and fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) were studied. Normalized glucose utilization rates (GURs) in the tumor were compared with GURs in histopathologically verified low-grade astrocytomas and high-grade tumors. RESULTS: All JPAs enhanced markedly after administration of contrast medium. Their glucose metabolism was significantly (P < .001) higher than that of low-grade astrocytomas and was similar to that of anaplastic astrocytomas. All patients with JPAs werein stable condition and showed no evidence of disease progression despite contrast enhancement and high tumoral glucose metabolism. CONCLUSION: The paradoxical FDG PET findings and enhancement at structural imaging might reflect the unusual vascularity of pilocytic tumors, and the increased GUR might be related to expression of the glucose transporter.

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Documento generato il 01/12/20 alle ore 16:36:41