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Titolo:
FURTHER EVALUATION OF A NEW PENETRATION ENHANCER, HPE-101
Autore:
YANO T; HIGO N; FUKUDA K; TSUJI M; NODA K; OTAGIRI M;
Indirizzi:
HISAMITSU PHARMACEUT CO INC,RES LABS,408 TASHIRO DAIKAN MACHI TOSU SAGA 841 JAPAN KUMAMOTO UNIV,FAC PHARMACEUT SCI KUMAMOTO 862 JAPAN
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 9, volume: 45, anno: 1993,
pagine: 775 - 778
SICI:
0022-3573(1993)45:9<775:FEOANP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERCUTANEOUS PENETRATION; SKIN PERMEATION; RAT SKIN; PROPYLENE-GLYCOL; HAIRLESS MOUSE; AZONE; DRUG; ABSORPTION; INVITRO; VEHICLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Yano et al., "FURTHER EVALUATION OF A NEW PENETRATION ENHANCER, HPE-101", Journal of Pharmacy and Pharmacology, 45(9), 1993, pp. 775-778

Abstract

The penetration enhancer, 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101), significantly enhanced the excretion of topically applied [C-14]indomethacin when dissolved in dipropylene glycol, triethylene glycol, diethylene glycol, 1,3-butylene glycol, trimethylene glycol, glycerin, water, silicone or triethanolamine, but not when dissolved in ethanol, isopropyl alcohol, oleyl alcohol, olive oil, peppermint oil, isopropyl myristate or hexylene glycol. HPE-101 significantly enhanced the excretion of [C-14]indomethacin, [C-14]nicotinic acid, [C-14]5-fluorouracil, [H-3]oestradiol and [H-3]triamcinolone acetonide, but not that of [H-3]testosterone. HPE-101 also significantly enhanced the excretion of [C-14]indomethacin applied to intact skin of rabbit, guinea-pig and rat, and to tape-stripped skin of guinea-pig, but did not enhance the excretion of [C-14]indomethacin applied to tape-stripped skin of rat or rabbit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:42:19