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Titolo:
A RECEPTOR FOR SUBGROUP-A ROUS-SARCOMA VIRUS IS RELATED TO THE LOW-DENSITY-LIPOPROTEIN RECEPTOR
Autore:
BATES P; YOUNG JAT; VARMUS HE;
Indirizzi:
UNIV PENN,SCH MED,DEPT MICROBIOL PHILADELPHIA PA 19104 UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS SAN FRANCISCO CA 94143
Titolo Testata:
Cell
fascicolo: 6, volume: 74, anno: 1993,
pagine: 1043 - 1051
SICI:
0092-8674(1993)74:6<1043:ARFSRV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECOTROPIC RETROVIRUS RECEPTOR; APE LEUKEMIA-VIRUS; MUTATIONAL ANALYSIS; GENE ENCODES; HOST RANGE; PROTEIN; INFECTION; SEQUENCE; CD4; DETERMINANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P. Bates et al., "A RECEPTOR FOR SUBGROUP-A ROUS-SARCOMA VIRUS IS RELATED TO THE LOW-DENSITY-LIPOPROTEIN RECEPTOR", Cell, 74(6), 1993, pp. 1043-1051

Abstract

Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Herewe have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular receptors for RSV(A). Predicted products of the processed genes appear to be small membrane-associated proteins with identical 83 amino acid extracellular domains but different membrane anchors. Within the extracellular domain is a region closely related to the ligand-binding repeat of the low density lipoprotein receptor (LDLR). Expression of either processed gene renders mammalian cells specifically susceptible to RSV(A). Antibodies directed against the receptor block subgroup A infection of avian cells via endogenous receptors and have no effect on entry of other RSV subgroups. Thus, small LDLR-related proteins are cellular receptors for RSV(A).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:23:03