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Titolo:
SMALL MOLECULES THAT SELECTIVELY BLOCK RNA-BINDING OF HIV-1 REV PROTEIN INHIBIT REV FUNCTION AND VIRAL PRODUCTION
Autore:
ZAPP ML; STERN S; GREEN MR;
Indirizzi:
UNIV MASSACHUSETTS,MED CTR,PROGRAM MOLEC MED WORCESTER MA 01605
Titolo Testata:
Cell
fascicolo: 6, volume: 74, anno: 1993,
pagine: 969 - 978
SICI:
0092-8674(1993)74:6<969:SMTSBR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONICALLY INFECTED-CELLS; TRANS-ACTIVATOR GENE; ARGININE-RICH MOTIF; MESSENGER-RNA; VIRUS-REPLICATION; SPLICING INVITRO; HTLV-III; EXPRESSION; TRANSCRIPTION; RECOGNITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Zapp et al., "SMALL MOLECULES THAT SELECTIVELY BLOCK RNA-BINDING OF HIV-1 REV PROTEIN INHIBIT REV FUNCTION AND VIRAL PRODUCTION", Cell, 74(6), 1993, pp. 969-978

Abstract

Replication of RNA viruses, such as the human immunodeficiency virus (HIV), is dependent upon multiple specific interactions between viral RNAs and viral and cellular proteins. A small molecule that interferesspecifically with one or more of these RNA-protein interactions couldbe an efficacious antiviral agent. Here we show that certain aminoglycoside antibiotics, in particular neomycin B, can block binding of theHIV Rev protein to its viral RNA recognition element. Inhibition appears to be highly selective, resulting from competitive binding of the drug to a small viral RNA region within the Rev-binding site. We further demonstrate that neomycin B can specifically antagonize Rev f unction in vitro and in vivo and can inhibit production of HIV. Our resultsestablish the feasibility for developing antiviral drugs that act by selectively blocking RNA-protein interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:20:21