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Titolo:
CANTHARIDIN, ANOTHER NATURAL TOXIN THAT INHIBITS THE ACTIVITY OF SERINE THREONINE PROTEIN PHOSPHATASES TYPE-1 AND TYPE-2A
Autore:
HONKANEN RE;
Indirizzi:
UNIV SO ALABAMA,COLL MED,DEPT BIOCHEM MOBILE AL 36688
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 330, anno: 1993,
pagine: 283 - 286
SICI:
0014-5793(1993)330:3<283:CANTTI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID; KINETIC-PARAMETERS; POTENT INHIBITOR; MICROCYSTIN-LR; IDENTIFICATION; PURIFICATION; TAUTOMYCIN; SITES;
Keywords:
CANTHARIDIN; SERINE THREONINE; PROTEIN; PHOSPHATASE; INHIBITOR; DEPHOSPHORYLATION; TOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Honkanen, "CANTHARIDIN, ANOTHER NATURAL TOXIN THAT INHIBITS THE ACTIVITY OF SERINE THREONINE PROTEIN PHOSPHATASES TYPE-1 AND TYPE-2A", FEBS letters, 330(3), 1993, pp. 283-286

Abstract

Cantharidin, a natural toxicant of blister beetles, is a strong inhibitor of protein phosphatases types 1(PPI) and 2A (PP2A). Like okadaic acid, cantharidin inhibits the activity of the purified catalytic subunit of PP2A (IC50 = 0.16 muM) at a lower concentration than that of PP1 (IC50 = 1.7 muM) and only inhibits the activity of protein phosphatase type 2B (PP2B) at high concentrations. Dose-inhibition studies conducted with whole cell homogenates indicate that cantharidin also inhibits the native forms of these enzymes. Thus, cantharidin, which is economical and readily available, may be useful as an additional probe for studying the functions of serine/threonine protein phosphatases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:09:40