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Titolo:
WHAT FACTORS DETERMINE IN-111 ANTIMYOSIN MONOCLONAL-ANTIBODY UPTAKE IN PATIENTS WITH MYOCARDIAL-INFARCTION
Autore:
OUZAN J; METZ D; JOLLY D; LIEHN JC; ELAERTS J;
Indirizzi:
4 RUE CHANZY F-51100 REIMS FRANCE CHU REIMS,ROBERT DEBRE HOSP F-51100 REIMS FRANCE INST JEAN GODINOI,DEPT NUCL MED F-51056 REIMS FRANCE
Titolo Testata:
International journal of cardiology
fascicolo: 3, volume: 40, anno: 1993,
pagine: 257 - 263
SICI:
0167-5273(1993)40:3<257:WFDIAM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOSIN-SPECIFIC ANTIBODY; IN-111 ANTIMYOSIN; LOCALIZATION; INJECTION; FAB;
Keywords:
ANTIMYOSIN MONOCLONAL ANTIBODIES; INFARCT SIZE; HEART LUNG RATIO UPTAKE; INFARCT RELATED CORONARY ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Ouzan et al., "WHAT FACTORS DETERMINE IN-111 ANTIMYOSIN MONOCLONAL-ANTIBODY UPTAKE IN PATIENTS WITH MYOCARDIAL-INFARCTION", International journal of cardiology, 40(3), 1993, pp. 257-263

Abstract

The intensity of indium-111 antimyosin monoclonal antibody uptake forvisualization of myocardial infarction seems partially dependent on the state of the infarct related coronary artery. The aim of this studyis to determine the factors which could account for the monoclonal antibody uptake variability. For this purpose, we investigated 27 patients (mean age 52.7 +/- 9.6 years) with a first proven myocardial infarction, by monoclonal antibody scintigraphy and coronary arteriography within the same period of time (7.12 +/- 6 days). The monoclonal antibody uptake was quantified by the heart/lung ratio on images recorded 24h after injection. The infarct size was quantitatively estimated on wall motion analysis of twelve segments in 30-degrees right anterior-oblique view with a radial method. The infarct related coronary artery state was assessed by the Thrombosis in Myocardial Infarction grade andthe functional characteristics of collateral vessels by Rentrop's classification. These three variables as well as location of myocardial infarction, left ventricular ejection fraction, administration of a thrombolytic therapy, delay between myocardial infarction and monoclonal antibody scintigraphy were studied using non parametric test, or by linear regression method in order to determine whether these factors would influence the heart/lung ratio. None of these parameters except infarct size was related to heart/lung ratio. Consequently, monoclonal antibody uptake is only dependent on the extent of infarcted myocardium and the intensity of uptake cannot predict the patency of an infarct related coronary artery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:55:16