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Titolo:
LOCALIZED PROTON MR SPECTROSCOPY OF THE BRAIN IN CHILDREN
Autore:
TZIKA AA; VIGNERON DB; BALL WS; DUNN RS; KIRKS DR;
Indirizzi:
HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT RADIOL,300 LONGWOOD AVE BOSTON MA 02115
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 5, volume: 3, anno: 1993,
pagine: 719 - 729
SICI:
1053-1807(1993)3:5<719:LPMSOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Keywords:
BRAIN, DISEASES; BRAIN, INJURIES; BRAIN, ISCHEMIA; BRAIN, MR; BRAIN NEOPLASMS, IN INFANTS AND CHILDREN; BRAIN NEOPLASMS, MR; MAGNETIC RESONANCE (MR), SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Tzika et al., "LOCALIZED PROTON MR SPECTROSCOPY OF THE BRAIN IN CHILDREN", Journal of magnetic resonance imaging, 3(5), 1993, pp. 719-729

Abstract

Small-voxel (3.0-8.0 cm3), magnetic resonance (MR) imaging-guided proton MR spectroscopy was performed in 54 patients (aged 6 days to 19 years) with intracranial masses (n = 16), neurodegenerative disorders (n= 34), and other neurologic diseases (n = 4) and in 23 age-matched control subjects without brain disease. A combined short TE (18 msec) stimulated-echo acquisition mode (STEAM) and long TE (135 and/or 270 msec) spin-echo point-resolved spatially localized spectroscopy (PRESS) protocol, using designed radio-frequency pulses, was performed at 1.5 T. STEAM spectra revealed short T2 and/or strongly coupled metabolites;prominent resonances were obtained from N-acetyl aspartate (NAA), choline-containing compounds (Cho), and total creatine (tCr). Lactate waswell resolved with the long TE PRESS sequence. Intracranial tumors were readily differentiated from cerebrospinal fluid (CSF) collections. All tumors showed low NAA, high Cho, and reduced tCr levels. Neurodegenerative disorders showed low or absent NAA levels and enhanced mobilelipid, glutamate and glutamine, and inositol levels, consistent with neuronal loss, gliosis, demyelination, and amino acid neurotoxicity. Preliminary experience indicates that proton MR spectroscopy can contribute in the evaluation of central nervous system abnormalities of infants and children.

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Documento generato il 01/12/20 alle ore 16:14:27