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Titolo:
IMMUNOLOCALIZATION OF RENAL KALLIKREIN-LIKE SUBSTANCE IN RAT URINARY-BLADDER
Autore:
ORFILA C; BOMPART G; LEPERT JC; SUC JM; GIROLAMI JP;
Indirizzi:
INSERM,CJF,91-07 F-31054 TOULOUSE FRANCE CHU RANGUEIL,SERV NEPHROL F-31054 TOULOUSE FRANCE
Titolo Testata:
Histochemical Journal
fascicolo: 9, volume: 25, anno: 1993,
pagine: 664 - 669
SICI:
0018-2214(1993)25:9<664:IORKSI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE KALLIKREIN; HUMAN-FIBROBLASTS; KININ SYSTEM; LOCALIZATION; KIDNEY; ENZYME; IDENTIFICATION; BRADYKININ; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Orfila et al., "IMMUNOLOCALIZATION OF RENAL KALLIKREIN-LIKE SUBSTANCE IN RAT URINARY-BLADDER", Histochemical Journal, 25(9), 1993, pp. 664-669

Abstract

The renal origin of kallikrein is now clearly established. However, the presence of kallikrein in urine raises questions about a possible physiological role of this enzyme at the urinary level. We have alreadydemonstrated the presence of kallikrein-like substance in rat ureter. For establishing the continuity of the presence of kallikrein-like substance along the urinary tract we have studied the localization of immunoreactive kallikrein-like substance in urinary bladder of the normal rat by immunohistochemical methods for light- and electron-microscopy, using an antibody against rat urinary kallikrein. By light microscopy, kallikrein-like substance was found to be associated with the lamina propria, which is the connective tissue component which constitutesone layer of the bladder wall. Weak staining was present in the smooth-muscle layer. By immuno-electron microscopy, kallikrein-like substance was localized in fibroblasts which were present in the connective tissue and which penetrated into the layer of smooth muscle; immunoreactivity was observed in endoplasmic reticulum, Golgi apparatus and freepolyribosomes. Immunolabelling was demonstrated in no other part of the wall bladder and in no other cellular component. The continuity of the presence of kallikrein-like substance from the kidney to the urinary bladder gives new indications concerning the significance of this system in renal physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 23:37:32