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Titolo:
REGULATION OF HISTAMINE-RELEASE FROM OXYNTIC MUCOSA
Autore:
CHUANG CN; CHEN MCY; SOLL AH;
Indirizzi:
VET ADM WADSWORTH MED CTR,MED SERV,CTR ULCER RES & EDUC LOS ANGELES CA 90073 VET ADM WADSWORTH MED CTR,RES SERV,CTR ULCER RES & EDUC LOS ANGELES CA 90073
Titolo Testata:
The Yale journal of biology & medicine
fascicolo: 6, volume: 65, anno: 1992,
pagine: 753 - 759
SICI:
0044-0086(1992)65:6<753:ROHFOM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSTATIN-CONTAINING CELLS; MULTIPLE ENDOCRINE NEOPLASIA; CANINE FUNDIC MUCOSA; PERFUSED RAT STOMACH; ACID-SECRETION; MAST-CELLS; GASTRIN RECEPTORS; GENE-EXPRESSION; PARIETAL-CELLS; CCK RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.N. Chuang et al., "REGULATION OF HISTAMINE-RELEASE FROM OXYNTIC MUCOSA", The Yale journal of biology & medicine, 65(6), 1992, pp. 753-759

Abstract

The regulation of histamine release from oxyntic mucosa is complex because of two potential sources of histamine: mast cells and enterochromaffin-like (ECL) cells. A gastrin-responsive histamine pool was identified in the rat oxyntic mucosa two decades ago, but these ECL cells from the rat have not yet been isolated or characterized in vitro. In vivo studies in canine and human mucosa have been more difficult because of the high content of histamine in mast cells. Using enzyme-dispersed canine oxyntic mucosal cells, we have studied regulation of histamine release from a mast cell-depleted fraction prepared by sequential elutriation and density gradient. Histamine-like immunoreactivity was demonstrated, using peroxidase-anti-peroxidase immunohistochemistry. After short-term culture, histamine was released in response to gastrin,cholecystokinin, carbachol, and forskolin. Somatostatin potently and effectively inhibited the response to gastrin. The cultures used for these studies also contained somatostatin cells, and, furthermore, the response to gastrin was enhanced by incubation with monoclonal antibodies to somatostatin. The latter findings suggested that somatostatin was acting in these cultures by a paracrine route. This pattern contrasts with that obtained in previous studies of canine oxyntic mucosal mast cells.

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Documento generato il 02/12/20 alle ore 14:47:17