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Titolo:
INVOLVEMENT OF DOPAMINE-RECEPTORS IN THE ANTIPSYCHOTIC PROFILE OF (-)ETICLOPRIDE
Autore:
GIULIANI D; FERRARI F;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT I-41100 MODENA ITALY
Titolo Testata:
Physiology & behavior
fascicolo: 4, volume: 61, anno: 1997,
pagine: 563 - 567
SICI:
0031-9384(1997)61:4<563:IODITA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; SUBSTITUTED BENZAMIDE; NUCLEUS-ACCUMBENS; H-3 ETICLOPRIDE; BINDING; AGONIST; ANTAGONISTS; FOREBRAIN; SND-919; INVITRO;
Keywords:
(-) ETICLOPRIDE; STEREOTYPY; KETAMINE; COCAINE; DA D-2/D-3 RECEPTORS; HYPERMOTILITY; PSYCHOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D. Giuliani e F. Ferrari, "INVOLVEMENT OF DOPAMINE-RECEPTORS IN THE ANTIPSYCHOTIC PROFILE OF (-)ETICLOPRIDE", Physiology & behavior, 61(4), 1997, pp. 563-567

Abstract

The present study was performed to assess the effects exerted by the dopamine (DA) D-2/D-3 antagonist (-) eticlopride on rodent behavioral models considered to be predictive of antipsychotic activity, namely, antagonism toward DA agonist-induced stereotyped behavior (SB), and ketamine- and cocaine-induced hypermotility. (-) Eticlopride (10-50 mu g/kg) dose-dependently inhibited SB elicited by SND 919 (10 mg/kg), CQP201-403 (0.5 mg/kg), and 7-OH-DPAT (5 mg/kg); moreover, it significantly counteracted the hypermotility induced in rats and mice by ketamine(5 and 10 mg/kg). When (-) eticlopride was injected before cocaine(15mg/kg) either acutely or subchronically administered in male rats, italso potently antagonized the hypermotility typically induced by the drug. These results are discussed in the light of putative D-2/D-3 receptor involvement, and are considered as predictive of antipsychotic potential. (C) 1997 Elsevier Science Inc.

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Documento generato il 18/01/20 alle ore 10:32:57