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Titolo:
USE OF PLASMA FERRITIN CONCENTRATION TO DIAGNOSE IRON-DEFICIENCY IN ELDERLY PATIENTS
Autore:
HOLYOAKE TL; STOTT DJ; MCKAY PJ; HENDRY A; MACDONALD JB; LUCIE NP;
Indirizzi:
UNIV GLASGOW,WESTERN INFIRM,DEPT HAEMATOL GLASGOW G11 6NT SCOTLAND UNIV GLASGOW,SO GEN HOSP,DEPT GERIATR MED GLASGOW G51 4TF SCOTLAND GARTNAVEL ROYAL HOSP,DEPT GERIATR MED GLASGOW SCOTLAND
Titolo Testata:
Journal of Clinical Pathology
fascicolo: 9, volume: 46, anno: 1993,
pagine: 857 - 860
SICI:
0021-9746(1993)46:9<857:UOPFCT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC DISEASE; ANEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Holyoake et al., "USE OF PLASMA FERRITIN CONCENTRATION TO DIAGNOSE IRON-DEFICIENCY IN ELDERLY PATIENTS", Journal of Clinical Pathology, 46(9), 1993, pp. 857-860

Abstract

Aims-To determine a concentration of ferritin below which the possibility of iron deficiency should be considered in elderly patients. Methods-Consecutive new referrals to a geriatric unit (n = 472) were studied prospectively. Full blood count, ferritin, serum vitamin B12 and red cell folate were measured for all patients. A blood film was assessed independently by three haematologists for features of iron deficiency. For those with ferritin of 12-45 ng/ml, bone marrow aspirates were performed and examined for the presence of stainable iron. When possible, a trial of oral iron was given to those with ferritin of less-than-or-equal-to 45 ng/ml and response was determined by remeasurement of full blood count and ferritin after a minimum of three weeks of treatment. Results-Bone marrow examination was performed in 32 patients withferritin of 12-45 ng/ml, of whom 27 (84%) had absent stainable iron, suggesting that most elderly patients with ferritin in this range haveiron deficiency. Compared with those with ferritin of 100-299 ng/ml, in whom iron stores were presumed to be normal, patients with ferritinof 12-45 ng/ml had a significantly lower mean haemoglobin and mean red blood cell volume. Furthermore, patients with ferritin up to 75 ng/ml had a significantly higher mean red cell distribution width, and were more likely to have an iron deficient blood film. Conclusion-Iron deficient erythropoiesis can occur in elderly patients with ferritin up to 75 ng/ml. This is much higher than the lower limit of the ''normal'' range usually quoted for younger subjects; this difference should betaken into account when ferritin concentrations are interpreted in elderly patients.

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Documento generato il 18/09/20 alle ore 11:14:52