Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE GENE FOR SPINAL CEREBELLAR ATAXIA-1 (SCA1) IS FLANKED BY 2 CLOSELY LINKED HIGHLY POLYMORPHIC MICROSATELLITE LOCI
Autore:
JODICE C; FRONTALI M; PERSICHETTI F; NOVELLETTO A; PANDOLFO M; SPADARO M; GIUNTI P; SCHINAIA G; LULLI P; MALASPINA P; PLASMATI R; TOLA R; ANTONELLI A; DIDONATO S; MOROCUTTI C; WEISSENBACH J; CANN HM; TERRENATO L;
Indirizzi:
CNR,IST MED SPERIMENTALE I-00137 ROME ITALY UNIV TOR VERGATA,DIPARTIMENTO BIOL I-00173 ROME ITALY OSPED BELLARIA I-40100 BOLOGNA ITALY IST NAZL NEUROL C BESTA I-20100 MILAN ITALY UNIV ROMA LA SAPIENZA,IST CLIN MALATTIE NERVOSE & MENTALI I-00185 ROME ITALY UNIV ROMA LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE I-00185 ROME ITALY UNIV FERRARA,IST CLIN NEUROL I-44100 FERRARA ITALY GENETHON F-91002 EVRY FRANCE CTR ETUD POLYMORPHISME HUMAINE F-75010 PARIS FRANCE CNR,IST MED SPERIMENTALE I-00137 ROME ITALY
Titolo Testata:
Human molecular genetics
fascicolo: 9, volume: 2, anno: 1993,
pagine: 1383 - 1387
SICI:
0964-6906(1993)2:9<1383:TGFSCA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOMINANT SPINOCEREBELLAR ATAXIA; DINUCLEOTIDE REPEAT POLYMORPHISM; LARGE ITALIAN KINDREDS; D6S89 LOCUS; LINKAGE; HLA; HETEROGENEITY; CLASSIFICATION; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Jodice et al., "THE GENE FOR SPINAL CEREBELLAR ATAXIA-1 (SCA1) IS FLANKED BY 2 CLOSELY LINKED HIGHLY POLYMORPHIC MICROSATELLITE LOCI", Human molecular genetics, 2(9), 1993, pp. 1383-1387

Abstract

The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM interval on 6p. Multipoint linkage analysis and haplotypes from recombinants map SCA1 between two of these markers, D6S274 and D6S259, 5 -6 cM apart. A single rare four marker haplotype within this interval shows linkage disequilibrium with the disease locus in southern Italy and is transmitted with SCA1 in five kindreds originating from this area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 07:53:00