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Titolo:
DEVELOPMENT OF THE VASCULATURE OF THE ANTERIOR-PITUITARY - ONTOGENY OF BASIC FIBROBLAST GROWTH-FACTOR
Autore:
SCHECHTER JE; PATTISON A; PATTISON T;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT ANAT & CELL BIOL,1333 SAN PABLO ST LOS ANGELES CA 90033
Titolo Testata:
Developmental dynamics
fascicolo: 2, volume: 197, anno: 1993,
pagine: 81 - 93
SICI:
1058-8388(1993)197:2<81:DOTVOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; FOLLICULO-STELLATE CELLS; EXTRACELLULAR-MATRIX; ANGIOGENIC PROTEIN; S-100 PROTEIN; DNA-SYNTHESIS; RAT; LOCALIZATION; FISCHER-344; MEMBRANE;
Keywords:
FIBROBLAST GROWTH FACTOR; PHAGOCYTES; FOLLICULOSTELLATE CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Schechter et al., "DEVELOPMENT OF THE VASCULATURE OF THE ANTERIOR-PITUITARY - ONTOGENY OF BASIC FIBROBLAST GROWTH-FACTOR", Developmental dynamics, 197(2), 1993, pp. 81-93

Abstract

This study correlates the ontogeny of basic fibroblast growth factor (FGF) with the development of the vasculature of the anterior pituitary (AP) in two strains of rat, Sprague-Dawley (SD) and Fischer 344 (F344). Immunolocalization of FGF was followed from the first appearance of Rathke's pouch (RP) in 12-day (12d) fetuses, through each day of fetal development, and in 5, 20, and 50d postnatal female rats. In addition, the ontogeny of folliculo-stellate cells (FSC) is described, sinceprevious studies suggested that these unique cells might function as phagocytes in the regulation of FGF. In both rat strains, vascularization of the AP commenced in 16d fetuses. In 15-20d fetuses, dense foci of immunopositivity for extracellular FGF were apparent at sites of capillary penetration adjacent to partially disrupted, immature gonadotropes. Localization of FGF was first detected in immature gonadotropes in 18d fetuses and persisted in the cytosol of a subpopulation of gonadotropes thereafter. In 15d fetuses, FGF was localized within the cytosol intimately associated with the peripheral-facing plasma membranes of all cells of the adenohypophysis, and persisted to variable degreesin later fetal stages. Localization of FGF within nuclei of AP parenchymal cells was evident only in 16-17d fetuses. Although the ontogeny of FGF and vascularization of the AP was very similar in both rat strains, the ontogeny of FSC differed markedly. In both strains, follicular lumens contained FGF during late fetal and early postnatal development. However, both electron microscopy and immunostaining for S-100 marker protein revealed that the postero-lateral edges of the AP of F344 rats often lacked FSC when compared to SD rats, a situation which could compromise regulation of FGF by FSC at the AP periphery in that strain, and thereby contribute to the neovascularization from systemic blood vessels known to occur in that strain during prolactinoma formation. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:13:28