Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF 5-HYDROXYTRYPTAMINE (5-HT) ON THE DISCHARGE OF VAGAL MECHANORECEPTORS AND MOTILITY IN THE UPPER GASTROINTESTINAL-TRACT OF THE FERRET
Autore:
BLACKSHAW LA; GRUNDY D;
Indirizzi:
UNIV SHEFFIELD,DEPT BIOMED SERV SHEFFIELD S10 2TN S YORKSHIRE ENGLAND UNIV SHEFFIELD,DEPT BIOMED SERV SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1, volume: 45, anno: 1993,
pagine: 51 - 59
SICI:
0165-1838(1993)45:1<51:EO5(OT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED FERRET; AFFERENT DISCHARGE; RECEPTOR; CHOLECYSTOKININ; RESPONSES; FIBERS; SHEEP;
Keywords:
5-HYDROXYTRYPTAMINE; VAGAL AFFERENT FIBER; GASTROINTESTINAL MOTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Blackshaw e D. Grundy, "EFFECTS OF 5-HYDROXYTRYPTAMINE (5-HT) ON THE DISCHARGE OF VAGAL MECHANORECEPTORS AND MOTILITY IN THE UPPER GASTROINTESTINAL-TRACT OF THE FERRET", Journal of the autonomic nervous system, 45(1), 1993, pp. 51-59

Abstract

This study was undertaken to investigate the sensitivity of vagal mechanoreceptor afferent fibres from the stomach and small intestine to 5-hydroxytryptamine (5-HT, 10 and 50 mug), and to relate this to motor activity. The discharge of single afferent fibres was recorded from the cervical vagus of Urethane anaesthetized ferrets. These had receptive fields in the corpus (15 fibres), antrum (11 fibres), duodenum (3 fibres) or jejunum (1 fibre), and their discharge was excited by distension of the segment containing the receptive field, or by mechanical probing. Conduction velocity was calculated in 7 fibres, and always fellin the C-fibre range (0.84 +/- 0.07 m/s). Injection of 5-HT intra-arterially via the coeliac axis evoked both contraction and relaxation with the dominant effect dependent on region and dose of 5-HT. However, irrespective of the motor response, the mechanoreceptor discharge closely mirrored both the magnitude and the time-course of the motor response. The relationship between the changes in discharge of individual mechanoreceptors and change in intraluminal pressure in all regions in response to both doses of 5-HT fitted a linear regression y = 17.1 +/-1.2x and was highly significant (P < 0.0001), indicating that 5-HT has no modulatory effect on the sensitivity of mechanoreceptors to changes in intraluminal pressure. This study suggests that vagal mechanoreceptors supplying the gastroinestinal tract respond to changes in motoractivity evoked by 5-HT, rather than to 5-HT directly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:40:55