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Titolo:
EFFECTS OF 5-HYDROXYTRYPTAMINE ON DISCHARGE OF VAGAL MUCOSAL AFFERENT-FIBERS FROM THE UPPER GASTROINTESTINAL-TRACT OF THE FERRET
Autore:
BLACKSHAW LA; GRUNDY D;
Indirizzi:
UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1, volume: 45, anno: 1993,
pagine: 41 - 50
SICI:
0165-1838(1993)45:1<41:EO5ODO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED FERRET; SMALL-INTESTINE; 5-HT3 RECEPTOR; GASTRIC ANTRUM; FIBERS; CHOLECYSTOKININ; CAT; ANTAGONISM; RESPONSES; SHEEP;
Keywords:
5-HYDROXYTRYPTAMINE; CHOLECYSTOKININ; SEROTONIN; VAGAL AFFERENT FIBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Blackshaw e D. Grundy, "EFFECTS OF 5-HYDROXYTRYPTAMINE ON DISCHARGE OF VAGAL MUCOSAL AFFERENT-FIBERS FROM THE UPPER GASTROINTESTINAL-TRACT OF THE FERRET", Journal of the autonomic nervous system, 45(1), 1993, pp. 41-50

Abstract

This study was undertaken to determine the effects of 5-hydroxytryptamine (5-HT) on vagal mucosal afferent endings and how this may relate to their sensitivity to other stimuli. Single afferent fibres with receptive fields in the mucosa of the upper gastrointestinal tract were recorded from the cervical vagus of Urethane anaesthetized ferrets. Theselection criteria included failure to respond to luminal distension (i.e., vagal tension receptors were excluded). All fibres tested responded to mucosal stroking. The majority of these (28/32) also respondedto close-intrarterially applied 5-HT (10 mug) with a brief burst (usually < 15 s) of action potentials, which in 6/6 cases was reduced or abolished by the 5-HT3 receptor antagonist granisetron (0.1-0.5 mg/kg i.v.), as were four responses to cholecystokinin-octapeptide (100-400 pmol close I.A.). The response to 5-HT was shown to be dose-dependent over the dose range 2-75 mug on six occasions. Responses to luminal stimuli, which included 150 mM HCl, 1 M NaCl, and mucosal stroking, were not blocked by granisetron although in three fibres, the resting discharge was reduced by the antagonist, suggesting that resting discharge in vagal mucosal afferents may be influenced by endogenously released 5-HT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:18:53