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Titolo:
VIRAL-INFECTIONS AND CHEMICAL EXPOSURES AS RISK-FACTORS FOR HEPATOCELLULAR-CARCINOMA IN VIETNAM
Autore:
CORDIER S; THUY LTB; VERGER P; BARD D; DAI LC; LAROUZE B; DAZZA MC; QUINH HT; ABENHAIM L;
Indirizzi:
INSERM,U170 F-94807 VILLEJUIF FRANCE FAC MED HANOI,COMM 10-80 HANOI VIETNAM IPSN,CEA,DPHD,SEGR,LEADS F-92265 FONTENAY ROSES FRANCE INSERM,U13 F-75019 PARIS FRANCE MCGILL UNIV,DEPT EPIDEMIOL MONTREAL H3A 2T5 QUEBEC CANADA
Titolo Testata:
International journal of cancer
fascicolo: 2, volume: 55, anno: 1993,
pagine: 196 - 201
SICI:
0020-7136(1993)55:2<196:VACEAR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY LIVER-CANCER; HEPATITIS-C VIRUSES; CIGARETTE-SMOKING; ALCOHOL; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S. Cordier et al., "VIRAL-INFECTIONS AND CHEMICAL EXPOSURES AS RISK-FACTORS FOR HEPATOCELLULAR-CARCINOMA IN VIETNAM", International journal of cancer, 55(2), 1993, pp. 196-201

Abstract

A case-control study investigating risk factors for hepatocellular carcinoma (HCC) was conducted in Hanoi, in the north of Vietnam, between1989 and 1992. Male cases of HCC (152) diagnosed in 2 hospitals were included. Hospital controls (241) admitted mainly to abdominal surgerydepartments were frequency-matched to cases for sex, age, hospital and place of residence (Hanoi, province). Odds ratios adjusted for matching variables and other potential confounders were estimated using unconditional logistic regression, or exact non-parametric statistical inference when numbers were small. Positivity for hepatitis B surface antigen (HBsAg) was the main risk factor for HCC in this sample. Five subjects (3 cases, 2 controls) had been infected by hepatitis C virus (HCV), and none of them were carriers of HBsAg, giving an OR of 38 associated with HCV infection among HBsAg-negative subjects. Alcohol drinking was associated with HCC and interacted with HBsAg positivity. Agricultural use of organophosphorous pesticides (30 liters/year or more) and military service in the south of Vietnam for 10 years or more were also associated with an increased risk of HCC. This study confirms themajor role played by HBV infection and its association with HCC in south-east Asia. It also suggests how other factors such as alcohol consumption or exposure to chemicals may interact with HBV infection. (C) 1993 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 08:57:33