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Titolo:
THE KIDNEY AND PRIMARY HYPERTENSION - CONTRIBUTIONS FROM RENAL-TRANSPLANTATION STUDIES IN ANIMALS AND HUMANS
Autore:
RETTIG R; SCHMITT B; PELZL B; SPECK T;
Indirizzi:
UNIV HEIDELBERG,DEPT PHARMACOL,NEUENHEIMER FELD 366 D-69120 HEIDELBERG GERMANY GERMAN INST HIGH BLOOD PRESSURE RES HEIDELBERG GERMANY
Titolo Testata:
Journal of hypertension
fascicolo: 9, volume: 11, anno: 1993,
pagine: 883 - 891
SICI:
0263-6352(1993)11:9<883:TKAPH->2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESSURE-NATRIURESIS RELATIONSHIP; SALT-RESISTANT RATS; BLOOD-PRESSURE; ALLOGRAFT RECIPIENTS; GENETIC INFLUENCE; GRAFT-SURVIVAL; SENSITIVE RATS; DAHL RATS; HOMOGRAFTS; POLYMORPHISM;
Keywords:
HYPERTENSION; KIDNEY; POSTTRANSPLANTATION HYPERTENSION; RENAL TRANSPLANTATION; SPONTANEOUSLY HYPERTENSIVE RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
R. Rettig et al., "THE KIDNEY AND PRIMARY HYPERTENSION - CONTRIBUTIONS FROM RENAL-TRANSPLANTATION STUDIES IN ANIMALS AND HUMANS", Journal of hypertension, 11(9), 1993, pp. 883-891

Abstract

Clinical studies: In clinical renal transplantation studies, recipients of a renal graft from a donor with a genetic predisposition to hypertension had higher blood pressures and required more antihypertensivetreatment than recipients of a renal graft from a normotensive donor. In addition, blood pressure normalization in patients suffering from essential hypertension by bilateral nephrectomy and subsequent transplantation of a kidney from a normotensive donor has been reported. The interpretation of these data may be limited by the large number of different factors that can contribute to post-transplantation hypertension in human renal transplant recipients. Experimental studies: In experimental renal transplantation studies the contribution of individual factors to post-transplantation hypertension can be independently assessed. Besides immunological graft rejection and hypertension-induced damage to the renal graft, a genetic predisposition to hypertension in the kidney donor has been demonstrated to be associated with post-transplantation hypertension in the recipient. Thus, normotensive recipients of a renal graft from a genetically hypertensive donor consistently developed post-transplantation hypertension in four different animal models of genetic hypertension. Furthermore, in genetically hypertensive rats bilateral nephrectomy together with transplantation of a kidneyfrom a normotensive donor has been shown to be associated with a decrease in blood pressure. Conclusions: Hypertension following renal transplantation may be due to a variety of factors, including immunological graft rejection, hypertension-induced damage to the renal transplantand a genetic predisposition to hypertension of the kidney donor. Thefinding that blood pressure is transplanted with the renal graft in genetic hypertension suggests a genetically determined alteration to the kidney as a major factor in the aetiology of primary hypertension. The nature of this factor is just beginning to be understood. Renal transplantation studies in rat models of genetic hypertension, combined with the tools of molecular biology, may help to provide further insights into the role of the kidney in primary hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:26:14