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Titolo:
T-HELPER CELL RECOGNITION OF MUSCLE ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS - EPITOPES ON THE GAMMA-SUBUNIT AND DELTA-SUBUNIT
Autore:
MANFREDI AA; PROTTI MP; DALTON MWM; HOWARD JF; CONTITRONCONI BM;
Indirizzi:
UNIV MINNESOTA,DEPT BIOCHEM,1479 GORTNER AVE ST PAUL MN 55108 UNIV MINNESOTA,DEPT PHARMACOL MINNEAPOLIS MN 55455 UNIV N CAROLINA,DEPT NEUROL CHAPEL HILL NC 27599
Titolo Testata:
The Journal of clinical investigation
fascicolo: 2, volume: 92, anno: 1993,
pagine: 1055 - 1067
SICI:
0021-9738(1993)92:2<1055:TCROMA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAIN IMMUNOGENIC REGION; MYELIN BASIC-PROTEIN; LYMPHOCYTES-T; ALPHA-SUBUNIT; MONOCLONAL-ANTIBODIES; SCID MICE; SYNTHETIC PEPTIDES; SEQUENCE-ANALYSIS; LINE TE671; B-CELLS;
Keywords:
EMBRYONIC ACETYLCHOLINE RECEPTOR; AUTOIMMUNITY; T-EPITOPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Manfredi et al., "T-HELPER CELL RECOGNITION OF MUSCLE ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS - EPITOPES ON THE GAMMA-SUBUNIT AND DELTA-SUBUNIT", The Journal of clinical investigation, 92(2), 1993, pp. 1055-1067

Abstract

We tested the response of CD4+ cells and/or total lymphocytes from the blood of 22 myasthenic patients and 10 healthy controls to overlapping synthetic peptides, 20 residues long, to screen the sequence of thegamma and delta subunits of human muscle acetylcholine receptor (AChR). The gamma subunit is part of the AChR expressed in embryonic muscleand is substituted in the AChRs of most adult muscles by an epsilon subunit. The delta subunit is present in both embryonic and adult AChRs. Adult extrinsic ocular muscles, which are preferentially and sometimes uniquely affected by myasthenic symptoms, and thymus, which has a still obscure but important role in the pathogenesis of myasthenia gravis, express the embryonic gamma subunit. Anti-AChR CD4+ responses weremore easily detected after CD8+ depletion. All responders recognized epitopes on both the gamma and delta subunits and had severe symptoms. In four patients the CD4+ cell response was tested twice, when the symptoms were severe and during a period of remission. Consistently, theresponse was only detectable, or larger, when the patients were severely affected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:40:29