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Titolo:
REDUCTION OF MOTOR IMPAIRMENT BY ADRENAL-MEDULLA TRANSPLANTS IN AGED RATS
Autore:
GARCIAHERNANDEZ F; PACHECOCANO MT; DRUCKERCOLIN R;
Indirizzi:
NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROSCI,APARTADO POSTAL 70600 MEXICO CITY 04510 DF MEXICO NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROSCI,APARTADO POSTAL 70600 MEXICO CITY 04510 DF MEXICO INST MEXICANO SEGURO SOCIAL,UNIDAD INVEST BIOMED BASICA MEXICO CITY 7DF MEXICO
Titolo Testata:
Physiology & behavior
fascicolo: 3, volume: 54, anno: 1993,
pagine: 589 - 598
SICI:
0031-9384(1993)54:3<589:ROMIBA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINERGIC FIBERS; PARKINSONS-DISEASE; CHROMAFFIN CELLS; BASAL GANGLIA; ENHANCE RECOVERY; PERIPHERAL-NERVE; CEBUS MONKEYS; CAUDATE; SURVIVAL; GRAFTS;
Keywords:
AGING; MOTOR IMPAIRMENT; ADRENAL MEDULLA; TRANSPLANTS; L-DOPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
F. Garciahernandez et al., "REDUCTION OF MOTOR IMPAIRMENT BY ADRENAL-MEDULLA TRANSPLANTS IN AGED RATS", Physiology & behavior, 54(3), 1993, pp. 589-598

Abstract

Recently we have reported that drugs that enhance dopaminergic transmission, such as L-dopa and D-amphetamine, substantially improve the age-related detetioration of extrapyramidal motor functions, as assessedby the narrow uphill beam test. Here we report the effect of fetal adrenal medullary transplants upon the motor performance of aged rats insuch a test. Rats were grafted with 300,000 cultured adrenal medullary cells, placed into the head of either the left caudate nucleus, or into both caudates. A third group was grafted with one freshly dissected adrenal medulla placed as a block of tissue into the lateral ventricle, whereas the control group sustained sham grafting. Evaluation of the motor performance of cultured and sham-grafted rats showed no improvement along the testing phase. Only adrenal block-grafted rats exhibited a significant recovery of motor coordination. Histologically, cultured cell grafts had a deteriorated appearance with poor survival rates, while block grafts exhibited chromaffin cells with round and neuron-like shapes. The results suggest that cultured adrenal grafts may notinduce motor improvement due to their extremely low survival and poorintegration, at least in the aged host brain, while fresh adrenal transplants may improve motor coordination for as long as 84 days.

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Documento generato il 02/04/20 alle ore 12:44:36