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Titolo:
INHIBITION OF ANTITUMOR EFFECTS OF FLAVONE ACETIC-ACID BY CORTISONE
Autore:
CHING LM; JOSEPH WR; BAGULEY BC;
Indirizzi:
UNIV AUCKLAND,SCH MED,CANC RES LAB,PRIVATE RAG 92019 AUCKLAND NEW ZEALAND
Titolo Testata:
Anticancer research
fascicolo: 4, volume: 13, anno: 1993,
pagine: 1139 - 1141
SICI:
0250-7005(1993)13:4<1139:IOAEOF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FLAVONE-8-ACETIC ACID; COLON-38 TUMORS; NSC-347512; INDUCTION; TOXICITY; INVIVO; AGENTS; CELLS; MICE;
Keywords:
MACROPHAGE; HEMORRHAGIC NECROSIS; COLON 38; LEWIS LUNG; MAMMARY M-16/C TUMOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Ching et al., "INHIBITION OF ANTITUMOR EFFECTS OF FLAVONE ACETIC-ACID BY CORTISONE", Anticancer research, 13(4), 1993, pp. 1139-1141

Abstract

The effect of cortisone (2 mg/mouse) on the effect of the antitumour agent flavone acetic acid (NSC 347512) was measured in four different murine tumours, growing subcutaneously. Response was measured by histological assessment of haemorrhagic necrosis after 24 h, and by assessment of tumour growth delay. In C57B1/6 x DBA/2)F1 hosts, cortisone pre-treatment prevented FAA-induced haemorrhagic necrosis in Lewis lung (sub-line LLTC) tumours but did not inhibit necrosis induction in Colon38 tumours. Similarly in C3H/HeN mice, cortisone pre-treatment prevented FAA-induced necrosis of Spon-2 and partially prevented necrosis induction in mammary M-16/C tumours. Since corticosteroids are often administered, or generated internally, in the course of clinical treatment, this result has implications for the clinical use of FAA and other compounds, which act on tumour vasculature as part of their antitumouraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:42:13