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Titolo:
CARBOPLATIN OTOTOXICITY - AN ANIMAL-MODEL
Autore:
WAKE M; TAKENO S; IBRAHIM D; HARRISON R; MOUNT R;
Indirizzi:
SUNNYBROOK HLTH SCI CTR,DEPT OTOLARYNGOL,SUITE A208,2075 BAYVIEW AVE TORONTO M4N 3HT ON CANADA AUDITORY SCI LAB TORONTO ON CANADA
Titolo Testata:
Journal of Laryngology and Otology
fascicolo: 7, volume: 107, anno: 1993,
pagine: 585 - 589
SICI:
0022-2151(1993)107:7<585:CO-AA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE CARBOPLATIN; PLATINUM; CANCER; ETOPOSIDE; CISPLATIN; ANALOGS;
Keywords:
CARBOPLATIN; OTOTOXICITY; ANIMAL LABORATORY; HAIR CELLS; MICROSCOPY, ELECTRON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Wake et al., "CARBOPLATIN OTOTOXICITY - AN ANIMAL-MODEL", Journal of Laryngology and Otology, 107(7), 1993, pp. 585-589

Abstract

A new animal model of ototoxicity is presented using intravenous carboplatin in adult chinchillas. A range of physiological and morphological effects was produced using doses calculated from the recommended therapeutic range (200-400 Mg/M2). Auditory thresholds to tone pips stimuli were monitored using brain stem evoked responses (ABR). Cochlear histopathology was studied by light microscopy (LM) and ultrstructural hair cell abnormalities investigated with scanning electronmicroscopy (SEM). Carboplatin in this animal model predominantly affected the inner hair cells. This may provide an important model for the study of selective loss of the main afferent input in the auditory system.

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Documento generato il 21/09/20 alle ore 12:51:53