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Titolo:
EXPRESSION OF A MITOGEN-INDUCIBLE CYCLOOXYGENASE IN BRAIN NEURONS - REGULATION BY SYNAPTIC ACTIVITY AND GLUCOCORTICOIDS
Autore:
YAMAGATA K; ANDREASSON KI; KAUFMANN WE; BARNES CA; WORLEY PF;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL BALTIMORE MD 21205 UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85724 UNIV ARIZONA,DEPT NEUROL TUCSON AZ 85724 UNIV ARIZONA,DIV NEURAL SYST MEMORY & AGING TUCSON AZ 85724
Titolo Testata:
Neuron
fascicolo: 2, volume: 11, anno: 1993,
pagine: 371 - 386
SICI:
0896-6273(1993)11:2<371:EOAMCI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE; RAT PREOVULATORY FOLLICLES; HORMONE-RELEASING HORMONE; ARACHIDONIC-ACID CASCADE; ANTI-INFLAMMATORY DRUGS; NITRIC-OXIDE SYNTHASE; FACTOR MESSENGER-RNAS; DENTATE GYRUS; LUTEINIZING-HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
K. Yamagata et al., "EXPRESSION OF A MITOGEN-INDUCIBLE CYCLOOXYGENASE IN BRAIN NEURONS - REGULATION BY SYNAPTIC ACTIVITY AND GLUCOCORTICOIDS", Neuron, 11(2), 1993, pp. 371-386

Abstract

Prostaglandins play important and diverse roles in the CNS. The firststep in prostaglandin synthesis involves enzymatic oxidation of arachidonic acid, which is catalyzed by prostaglandin H(PGH) synthase, alsoreferred to as cyclooxygenase. We have cloned an inducible form of this enzyme from rat brain that is nearly identical to a murine, mitogen-inducible cyclooxygenase identified from fibroblasts. Our studies indicate that this gene, here termed COX-2, is expressed throughout the forebrain in discrete populations of neurons and is enriched in the cortex and hippocampus. Neuronal expression is rapidly and transiently induced by seizures or NMDA-dependent synaptic activity. No expression is detected in glia or vascular endothelial cells. Basal expression of COX-2 appears to be regulated by natural synaptic activity in the developing and adult brain. Both basal and induced expression of COX-2 areinhibited by glucocorticoids, consistent with COX-2 regulation in peripheral tissues. Our studies indicate that COX-2 expression may be important in regulating prostaglandin signaling in brain. The marked inducibility in neurons by synaptic stimuli suggests a role in activity-dependent plasticity.

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Documento generato il 20/09/20 alle ore 22:15:16