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Titolo:
NEURAL CONTROL OF THE ENDOCRINE RAT-HEART
Autore:
JIAO JH; BAERTSCHI AJ;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT MOLEC PHYSIOL & BIOL PHYS CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT MOLEC PHYSIOL & BIOL PHYS CHARLOTTESVILLE VA 22908
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 16, volume: 90, anno: 1993,
pagine: 7799 - 7803
SICI:
0027-8424(1993)90:16<7799:NCOTER>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; AUTONOMIC NERVOUS-SYSTEM; PULMONARY-HYPERTENSION; VENTRICULAR MYOCARDIUM; ANESTHETIZED RABBIT; CONSCIOUS RATS; FACTOR RELEASE; ANF RELEASE; SECRETION; NORADRENALINE;
Keywords:
ATRIAL PEPTIDE; SCORPION VENOM; SODIUM CHANNELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Jiao e A.J. Baertschi, "NEURAL CONTROL OF THE ENDOCRINE RAT-HEART", Proceedings of the National Academy of Sciences of the United Statesof America, 90(16), 1993, pp. 7799-7803

Abstract

Although atrial stretch is the accepted stimulus for atrial natriuretic factor (ANF), in vivo studies suggest a stretch-independent, neurally induced ANF release mechanism. Thus the hypothesis that cardiac nerves can stimulate ANF secretion was tested in the Langendorff-perfused, paced rat heart. Venom from the scorpion Centruroides sculpturatus was used to activate neuronal sodium channels, veratridine was added toactivate sodium channels (predominantly in myocytes), and electrical stimulation was applied to the right atrial appendage. The efficacy ofnerve stimulation was verified by measurements of increased neuropeptide Y in the effluent. ANF levels in the effluent increased by 120% over baseline with 0.5 muM scorpion venom and by 88% with 0.5 muM veratridine (P < 0.01). Cardiac mechanics did not explain the large, concentration-dependent ANF response to the scorpion venom, since changes in the left ventricular developed pressure were small, opposite to those induced by veratridine, and unaffected by sympathectomy or adrenergic receptor blockade. Prior chemical sympathectomy and adrenergic receptor blockade almost abolished the ANF response to scorpion venom but hardly affected the ANF response to veratridine. Addition of 1 muM tetrodotoxin abolished an ANF responses. Electrical stimulation of the atrial appendage increased the ANF secretion by 60.2% (P < 0.02), in conjunction with neuropeptide Y, whereas control stimulations were ineffective. These studies unequivocally demonstrate that stimulation of cardiac sympathetic nerves potently stimulates ANF secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:02:08