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Titolo:
THE FRUSEMIDE TEST - SIMPLE SCREENING-TEST FOR RENAL ACIDIFICATION DEFECT IN UROLITHIASIS
Autore:
REYNOLDS TM; BURGESS N; MATANHELIA S; BRAIN A; PENNEY MD;
Indirizzi:
ROYAL GWENT HOSP,DEPT CHEM PATHOL,CARDIFF RD NEWPORT NP9 2UB GWENT WALES UNIV HOSP WALES,DEPT UROL CARDIFF CF4 4XN S GLAM WALES CARDIFF ROYAL INFIRM CARDIFF CF2 1SZ S GLAM WALES
Titolo Testata:
British Journal of Urology
fascicolo: 2, volume: 72, anno: 1993,
pagine: 153 - 156
SICI:
0007-1331(1993)72:2<153:TFT-SS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CITRATE EXCRETION; ACID-BASE TRANSPORT; STONE-FORMERS; TUBULAR-ACIDOSIS; CALCIUM; NEPHROLITHIASIS; FUROSEMIDE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Reynolds et al., "THE FRUSEMIDE TEST - SIMPLE SCREENING-TEST FOR RENAL ACIDIFICATION DEFECT IN UROLITHIASIS", British Journal of Urology, 72(2), 1993, pp. 153-156

Abstract

Urinary pH was first labelled as a risk factor for patients with recurrent calcium stone disease of the renal tract in 1978. The standard diagnostic test for patients with a history of stones, who appear to have urinary acidification defects is the ammonium chloride test. However, the performance of this test results in significant morbidity, particularly nausea and vomiting, and as a result there is little enthusiasm for screening for such defects. We describe a screening test that may be used to determine which patients require more definitive testing. It involves an oral dose of frusemide (40 mg) followed by half -hourly urine sampling for pH. For the detection of a renal tubular acidification defect, the frusemide test had sensitivity = 100%, specificity = 82%, predictive value of a positive result = 40%, predictive value of a negative result = 100%, screening efficiency = 84%, and there was no morbidity. During the ammonium chloride test 80% of the patients vomited or felt very nauseated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:37:37