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Titolo:
INDUCTION OF PROTECTIVE IMMUNITY AGAINST CORONAVIRUS-INDUCED ENCEPHALOMYELITIS - EVIDENCE FOR AN IMPORTANT ROLE OF CD8-CELLS IN-VIVO( T)
Autore:
FLORY E; PFLEIDERER M; STUHLER A; WEGE H;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNOBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY UNIV WURZBURG,INST VIROL & IMMUNOBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY
Titolo Testata:
European Journal of Immunology
fascicolo: 8, volume: 23, anno: 1993,
pagine: 1757 - 1761
SICI:
0014-2980(1993)23:8<1757:IOPIAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MOUSE HEPATITIS-VIRUS; VACCINIA-RECOMBINANT VIRUS; CYTOTOXIC LYMPHOCYTES-T; DEMYELINATING ENCEPHALOMYELITIS; NUCLEOCAPSID PROTEIN; NUCLEOTIDE-SEQUENCE; LETHAL INFECTION; INVITRO MODELS; MHV-JHM;
Keywords:
CORONAVIRUS MHV-JHM; ENCEPHALOMYELITIS; VACCINATION; PROTECTION; T-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
E. Flory et al., "INDUCTION OF PROTECTIVE IMMUNITY AGAINST CORONAVIRUS-INDUCED ENCEPHALOMYELITIS - EVIDENCE FOR AN IMPORTANT ROLE OF CD8-CELLS IN-VIVO( T)", European Journal of Immunology, 23(8), 1993, pp. 1757-1761

Abstract

Coronavirus MHV-JHM infections of rats provide useful models to studythe pathogenesis of virus-induced central nervous system disease.To analyze the role of the immune response against defined MHV-JHM antigens, we tested the protective efficacy of vaccinia virus (VV) recombinants expressing either the nucleocapsid (N) or the spike (S) protein. A strong protection was mediated in animals by immunization with recombinant VV encoding a wild-type S protein (VV-S(wildtype)), whereas VV recombinant expressing a mutant S354CR protein (VV)S354CR) had no protective effect. Recombinant VV encoding N protein (VV-N) induces a humoral and a CD4+ T cell response, but did not prevent acute disease regardless of the immunization protocol. In these experiments, challenge with an otherwise lethal dose of MHV-JHM was performed prior to the induction of virus-neutralizing antibodies and studies with the anti-CD8+ monoclonal antibody, MRC OX8 showed that elimination of the CD8+ subsetof T cells abrogates the protective effect. This result indicates that CD8+ T cells primed by recombinant VV expressing wild-type S proteinare a primary mechanism of immunological defense against MHV-JHM infection in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:41:15