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Titolo:
BLOCKADE OF ALPHA(2)-ADRENOCEPTORS PROTECTS THE VAGAL BAROREFLEX SYSTEM FROM TRANSIENT GLOBAL CEREBRAL-ISCHEMIA IN DOGS
Autore:
KURIHARA J; TAMAOKI S; KATO H;
Indirizzi:
TEIKYO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL SAGAMIKO KANAGAWA 19901JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 240, anno: 1993,
pagine: 73 - 76
SICI:
0014-2999(1993)240:1<73:BOAPTV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCOMPLETE ISCHEMIA; HYPOPERFUSION; DYSFUNCTION; IFENPRODIL; AGENTS; RAT;
Keywords:
CEREBRAL ISCHEMIA; BAROREFLEX (VAGAL); ALPHA(2)-ADRENOCEPTOR BLOCKADE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
J. Kurihara et al., "BLOCKADE OF ALPHA(2)-ADRENOCEPTORS PROTECTS THE VAGAL BAROREFLEX SYSTEM FROM TRANSIENT GLOBAL CEREBRAL-ISCHEMIA IN DOGS", European journal of pharmacology, 240(1), 1993, pp. 73-76

Abstract

Ifenprodil, phentolamine, yohimbine or idazoxan, 1 mg/kg i.v., administered 5 min prior to 5-min global cerebral ischemia, completely prevented the post-ischemic dysfunction of the vagal baroreflex in anesthetized dogs. Idazoxan, 0.1 mg/kg i.v., was cerebroprotective against mild ischemia, but ineffective against severe ischemia. The post-ischemicadministration of idazoxan, 1 mg/kg iv., failed to restore the damaged vagal baroreflex. These results suggest that blockade of alpha2-adrenoceptors during ischemia and the early reperfusion period may protectthe vagal component of baroreflex from cerebral ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:43:51