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Titolo:
MAPPING HISTOLOGY TO METABOLISM - COREGISTRATION OF STAINED WHOLE-BRAIN SECTIONS TO PREMORTEM PET IN ALZHEIMERS-DISEASE
Autore:
MEGA MS; CHEN SS; THOMPSON PM; WOODS RP; KARACA TJ; TIWARI A; VINTERS HV; SMALL GW; TOGA AW;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LAB NEUROIMAGING,DIV BRAINMAPPING LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT PATHOL & LAB MED,SECT NEUROPATHOLLOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT & BIOBEHAV SCI LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,ALZHEIMERS DIS CTR LOS ANGELES CA 90024
Titolo Testata:
NeuroImage
fascicolo: 2, volume: 5, anno: 1997,
pagine: 147 - 153
SICI:
1053-8119(1997)5:2<147:MHTM-C>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; SENILE DEMENTIA; DIAGNOSIS; )FLUORODEOXYGLUCOSE-F-18; STIMULATION; ASYMMETRIES; RAT; MRI; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Mega et al., "MAPPING HISTOLOGY TO METABOLISM - COREGISTRATION OF STAINED WHOLE-BRAIN SECTIONS TO PREMORTEM PET IN ALZHEIMERS-DISEASE", NeuroImage, 5(2), 1997, pp. 147-153

Abstract

The association between [F-18]fluorodeoxyglucose positron emission tomography (FDG-PET) counts obtained 8 h before death and neurofibrillary tangle (NFT) staining density in a patient with Alzheimer's disease (AD) was evaluated. In our patient FDG-PET counts were globally decreased with a greater focal deficit in the left medial temporal region independent of volume loss. After death, whole-brain sections derived from cryomacrotome sectioning were stained for NFTs by the Gallyas method and elastically warped into their native space enabling registrationwith premortem FDG-PET data. Gallyas staining density was localized to the paralimbic cortex of the basal forebrain, medial temporal, and orbital frontal regions. The poor correlation between NFT staining density and hypometabolism on FDG-PET implicates alternate mechanisms underlying the metabolic defect in AD. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:05:19