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Titolo:
CYTOCHROME-C-OXIDASE DEFECTS OF THE HUMAN SUBSTANTIA-NIGRA IN NORMAL AGING
Autore:
ITOH K; WEIS S; MEHRAEIN P; MULLERHOCKER J;
Indirizzi:
UNIV MUNICH,INST NEUROPATHOL,THALKIRCHNERSTR 36 D-80337 MUNICH GERMANY UNIV MUNICH,INST NEUROPATHOL D-80337 MUNICH GERMANY UNIV MUNICH,INST PATHOL D-80337 MUNICH GERMANY
Titolo Testata:
Neurobiology of aging
fascicolo: 6, volume: 17, anno: 1996,
pagine: 843 - 848
SICI:
0197-4580(1996)17:6<843:CDOTHS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGROSTRIATAL DOPAMINERGIC SYSTEM; KEARNS-SAYRE SYNDROME; TREATED YOUNG MICE; MITOCHONDRIAL-DNA; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; HUMAN BRAIN; INSITU HYBRIDIZATION; PARTIAL RECOVERY; MUSCLE-FIBERS;
Keywords:
NORMAL AGING; SUBSTANTIA NIGRA; CYTOCHROME C OXIDASE (COX); HUMAN; MORPHOMETRY; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
K. Itoh et al., "CYTOCHROME-C-OXIDASE DEFECTS OF THE HUMAN SUBSTANTIA-NIGRA IN NORMAL AGING", Neurobiology of aging, 17(6), 1996, pp. 843-848

Abstract

Based on morphological, biochemical, and molecular biologic analyses,degeneration of the dopaminergic nigrostriatal system has been reported to occur with normal aging. In the present study, the substantia nigra of 36 human brains with normal aging was investigated by means of morphometry and immunohistochemistry. The anteromedial (Am), anterointermediolateral (Ail), posteromedial (Pl), and posterolateral (PI) nuclei of the substantia nigra were analyzed using antibodies directed against the subunits II/III of cytochrome c oxidase (COX), the complex IVof the respiratory chain. The numerical density of melanin-positive neurons with COX defects was significantly increased in the four investigated nuclei, namely Am, Ail, Pm, and PI. These cells did not show any histologic signs of degeneration. The numerical density of melanin-positive neurons without COX defects was decreased with aging. Tne dataof the present study indicate that complex IV defects of neurons in the substantia nigra might be one cause of neuronal dysfunction occurring during aging. Copyright (C) 1996 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 20:00:42