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Titolo:
PATTERNS OF LOCAL CONNECTIVITY IN THE NEOCORTEX
Autore:
NICOLL A; BLAKEMORE C;
Indirizzi:
SCH MED SCI,DEPT PHYSIOL BRISTOL BS8 1TD ENGLAND UNIV OXFORD,PHYSIOL LAB OXFORD OX1 3PT ENGLAND
Titolo Testata:
Neural computation
fascicolo: 5, volume: 5, anno: 1993,
pagine: 665 - 680
SICI:
0899-7667(1993)5:5<665:POLCIT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY VISUAL-CORTEX; CROSS-CORRELATION ANALYSIS; CAT STRIATE CORTEX; PYRAMIDAL NEURONS; QUANTAL ANALYSIS; DENDRITIC MORPHOLOGY; HIPPOCAMPAL SLICES; PROJECTION NEURONS; AXON COLLATERALS; GRANULE CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Nicoll e C. Blakemore, "PATTERNS OF LOCAL CONNECTIVITY IN THE NEOCORTEX", Neural computation, 5(5), 1993, pp. 665-680

Abstract

Dual intracellular recording of nearby pairs of pyramidal cells in slices of rat visual cortex has shown that there are significant differences in functional connectivity between the superficial and deep layers (Mason et al. 1991; Nicoll and Blakemore 1993). For pairs of cells no farther than 300 mum apart, synaptic connections between layer 2/3 pyramidal neurons were individually weaker (median peak amplitude, A, of single-fiber excitatory postsynaptic potentials, EPSPs, = 0.4 mV) but more frequent (connection probability, p = 0.087) than those betweenlayer 5 pyramidal neurons (mean A = 0.8 mV, p < 0.015). Taken in combination with plausible estimates of the density of pyramidal cells, the total numbers of synapses on them and the number of synapses formed on their intracortical axons, the present analysis of the above data suggests that roughly 70% of the excitatory synapses on any layer 2/3 pyramid, but fewer than 1% of those on a layer 5 pyramidal neuron, are derived from neighboring pyramidal neurons in its near vicinity. Even assuming very extreme values for some parameters, chosen to erode thisdifference, the calculated proportion of ''local synapses'' for layer5 pyramids was always markedly lower than f or layer 2/3 pyramidal neurons. These results imply that local excitatory connections are much more likely to provide significant ''intracortical amplification'' of afferent signals in layer 2/3 than in layer 5 of rat visual cortex.

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Documento generato il 13/07/20 alle ore 05:11:10