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Titolo:
BIOACTIVE GLASS PROMOTED FORMATION OF NODULES IN PERIODONTAL-LIGAMENTFIBROBLASTS IN-VITRO
Autore:
KUBO K; KAKIMOTO T; KANDA C; TSUKASA N; UEHARA M; IZUMI Y; KAMADA T; KANEKO N; SUEDA T;
Indirizzi:
KAGOSHIMA UNIV,SCH DENT,DEPT PERIODONTOL,8-35-1 SAKURAGAOKA KAGOSHIMA890 JAPAN KAGOSHIMA UNIV,SCH DENT,DEPT PERIODONTOL,8-35-1 SAKURAGAOKA KAGOSHIMA890 JAPAN NIKON INC,SAGAMIHARA PLANT,DEPT TECHNOL DEV,BIOMED ENGN LAB SAGAMIHARA KANAGAWA JAPAN KAGOSHIMA UNIV,FAC MED,DEPT LAB MED KAGOSHIMA 890 JAPAN
Titolo Testata:
Journal of biomedical materials research
fascicolo: 9, volume: 27, anno: 1993,
pagine: 1175 - 1180
SICI:
0021-9304(1993)27:9<1175:BGPFON>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS; PHOSPHATASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K. Kubo et al., "BIOACTIVE GLASS PROMOTED FORMATION OF NODULES IN PERIODONTAL-LIGAMENTFIBROBLASTS IN-VITRO", Journal of biomedical materials research, 27(9), 1993, pp. 1175-1180

Abstract

The effects of bioactive glass and vitamin D3 on cultured fibroblastsderived from periodontal-ligament, with respect to their proliferation and alkaline-phosphatase activity were studied. The cells were cultured with or without the bioactive glass and/or vitamin D3, then the number and alkaline-phosphatase activity of the cells were measured periodically until the 33rd day. Formation of mineralized deposits was assessed by staining with alizarin red and von Kossa staining techniques. Fewer fibroblasts grew when they were cultured in the presence of bioactive glass and/or vitamin D3 as compared to those cultures without them. Alkaline-phosphatase activity was greater in the fibroblasts cultured with bioactive glass and vitamin D3 than in the cells grown without them. Mineralized deposits assessed by alizarin red and von Kossa staining techniques were observed microscopically around the fibroblasts cultured with bioactive glass and/or vitamin D3. A nodule visible after drying was evident only when both bioactive glass and vitamin D3 were present in culture. The results showed that although the bioactiveglass and vitamin D3 decreased cell proliferation, they increased thealkaline-phosphatase activity of the fibroblasts which formed a nodule, suggesting an effect which might be useful for implant materials. (C) 1993 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:07:07