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Titolo:
ANTINEUTROPHIL CYTOPLASM AUTOANTIBODIES - SPECIFICITY IN RENAL VASCULITIS
Autore:
SOLER C; DUPREGOUDABLE C; REY JP; MODESTO A; OKSMAN F; SUC JM;
Indirizzi:
CHU PURPAN,AUTOIMMUNITE LAB F-31059 TOULOUSE FRANCE CHU RANGUEIL,SERV NEPHROL F-31052 TOULOUSE FRANCE
Titolo Testata:
Annales de biologie clinique
fascicolo: 2, volume: 51, anno: 1993,
pagine: 133 - 139
SICI:
0003-3898(1993)51:2<133:ACA-SI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
FRE
Soggetto:
SYSTEMIC VASCULITIS; WEGENERS GRANULOMATOSIS; ANTIMYELOPEROXIDASE ANTIBODIES; CRESCENTIC GLOMERULONEPHRITIS; DISEASE; ANCA; MYELOPEROXIDASE; ASSOCIATIONS;
Keywords:
AUTOANTIBODIES; KIDNEY VASCULAR DISEASES; MYELOPEROXIDASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C. Soler et al., "ANTINEUTROPHIL CYTOPLASM AUTOANTIBODIES - SPECIFICITY IN RENAL VASCULITIS", Annales de biologie clinique, 51(2), 1993, pp. 133-139

Abstract

We present a retrospective study of all patients with a positive anti-neutrophil cytoplasm autoantibodies (ANCA) result from July 1987 to December 1990. The aims of the study were to assess specificity of ANCAin renal vasculitis and to correlate ANCA immunofluorescence subtypeswith clinical aspect, diagnosis, severity and outcome. Anti-myeloperoxidase antibody (A-MPO) was sought in 31 cases. Specificity was 86% and false-positive results were 11%. ANCA subtypes varied with the clinical picture. C-ANCA were more often present when renal vasculitis was associated with pulmonary and ear, nose and throat involvement; P-ANCAwere more often present when there was no respiratory tract involvement. Thus C-ANCA were preferentially associated with Wegener's granulomatosis and P-ANCA with microscopic polyarteritis and pauci-immune necrotizing and crescentic glomerulonephritis. No correlation was found between ANCA subtypes and severity or outcome. A-MPO were positive in 14cases (especially in micropolyarteritis and necrotizing glomerulonephritis).

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Documento generato il 04/12/20 alle ore 06:36:06