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Titolo:
DETERMINANTS OF BENEFICIAL EFFECT OF HEPARIN EXERCISE TREATMENT ON TREADMILL CAPACITY AND LONG-TERM EFFICACY OF THE THERAPY IN PATIENTS WITH CHRONIC EFFORT ANGINA
Autore:
EJIRI M; FUJITA M; HIRAI T; YAMANISHI K; MIWA K;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,DEPT INTERNAL MED 2,2630 SUGITANI TOYAMATOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,DEPT INTERNAL MED 2,2630 SUGITANI TOYAMATOYAMA 93001 JAPAN
Titolo Testata:
Japanese Circulation Journal
fascicolo: 8, volume: 57, anno: 1993,
pagine: 769 - 774
SICI:
0047-1828(1993)57:8<769:DOBEOH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; COLLATERAL CIRCULATION; CONSCIOUS DOGS;
Keywords:
ANGINA PECTORIS; CORONARY COLLATERAL CIRCULATION; RATE-PRESSURE PRODUCT; TREADMILL CAPACITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M. Ejiri et al., "DETERMINANTS OF BENEFICIAL EFFECT OF HEPARIN EXERCISE TREATMENT ON TREADMILL CAPACITY AND LONG-TERM EFFICACY OF THE THERAPY IN PATIENTS WITH CHRONIC EFFORT ANGINA", Japanese Circulation Journal, 57(8), 1993, pp. 769-774

Abstract

The purpose of the present study was to evaluate the factors which influence the effect of heparin exercise treatment on treadmill capacity, and to examine the long-term efficacy of the treatment in 16 patients with chronic effort angina. Treadmill exercise was performed 20 times for 2 to 3 weeks according to standard Bruce protocol. A single intravenous dose of heparin (5,000 IU) was given 10 min before each exercise period. Exercise with heparin pretreatment increased the total exercise duration from 6.6+/-1.6 (SD) to 9.4+/-1.9 min (p<0.05) and the maximal rate-pressure product from 19,200+/-4,700 to 24,700+/-5,900 mmHg.beats/min (p<0.05). The rate-pressure product at the onset of angina was also increased by 32% (p<0.05). The ST segment depression at the same exercise time as in control exercise was ameliorated from 0.16 +/-0.05 to 0.12 +/- 0.06 mV (p<0.05). Multivariate analysis of the determinants of the effect of the treatment on treadmill capacity indicatedthat the treatment is more effective in patients without previous myocardial infarction. All of the above-mentioned variables of treadmill capacity did not change significantly during a follow-up period of 13+/-7 months (range; 4-24 months). These findings lend further support to heparin exercise treatment as a possible therapeutic approach in patients with chronic stable effort angina, and particularly in those without previous infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:46:27