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Titolo:
COMPARISON OF 4 POTENTIAL MR PARAMETERS FOR SEVERE TISSUE DESTRUCTIONIN MULTIPLE-SCLEROSIS LESIONS
Autore:
VANWAESBERGHE JHT; CASTELIJNS JA; SCHELTENS P; TRUYEN L; NIJEHOLT GJLA; HOOGENRAAD FG; POLMAN CH; VALK J; BARKHOF F;
Indirizzi:
VRIJE UNIV AMSTERDAM,ACAD HOSP,MR CTR MS RES,DEPT DIAGNOST RADIOL,DE BOELELAAN 1117 NL-1081 HV AMSTERDAM NETHERLANDS
Titolo Testata:
Magnetic resonance imaging
fascicolo: 2, volume: 15, anno: 1997,
pagine: 155 - 162
SICI:
0730-725X(1997)15:2<155:CO4PMP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; MAGNETIZATION TRANSFER CONTRAST; DISABILITY; IMAGES; GUIDELINES; DISEASE; MS;
Keywords:
SCLEROSIS, MULTIPLE; BRAIN, MR; MAGNETIZATION TRANSFER CONTRAST; T-1 RELAXATION TIME; MAGNETIC RESONANCE; TISSUE CHARACTERIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.H.T. Vanwaesberghe et al., "COMPARISON OF 4 POTENTIAL MR PARAMETERS FOR SEVERE TISSUE DESTRUCTIONIN MULTIPLE-SCLEROSIS LESIONS", Magnetic resonance imaging, 15(2), 1997, pp. 155-162

Abstract

The purpose of this study was, first, to evaluate correlations between four potential magnetic resonance (MR) parameters for severe tissue destruction in multiple sclerosis (MS) lesions. Second, to evaluate the effect of incidental magnetization transfer (MT) effect on hypointense lesions in multislice T-1 spin echo (SE) imaging, In 49 lesions, from 10 MS patients, MT ratio (MTR), T-1 relaxation time, signal intensity (SI) on T-1-weighted SE images normalized to normal-appearing whitematter (NAWM), and SI normalized to cerebrospinal fluid (CSF) were measured, Differences in contrast of hypointense lesions were measured between single slice and multislice imaging. MTR correlated significantly (p < .001) with longitudinal relaxation rates (1/T-1) (r = 0.84), SI normalized to NAWM (r = 0.78), and SI normalized to CSF (r = 0.75). The degree of reduction in contrast, caused by multislice imaging, correlated significantly with MTR of lesions (r = 0.60, p < .001), leading to reduction of hypointense lesion load (p < .01). We conclude that all four MR markers for severe tissue destruction are highly correlated when applied to selected hypointense lesions on T-1-weighted SE images. Due to ''incidental'' off-resonance excitation, contrast and hypointense lesion load will be reduced in multislice T-1-weighted SE images. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:39:45